Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer

S Yuan, D She, S Jiang, N Deng, J Peng, L Ma - Molecular Medicine, 2024 - Springer
… Consequently, therapeutic strategies targeting ER stress-related interventions have attracted
… ER stress in cancer, metabolic, and neurodegenerative diseases, offering novel therapeutic

Homogeneous MMR deficiency throughout the entire tumor mass occurs in a subset of colorectal neuroendocrine carcinomas

C Fraune, R Simon, C Hube-Magg… - Endocrine …, 2020 - Springer
… , demanding novel treatment strategies such as immune checkpoint inhibition in tumors with
… of 10) but highly infrequent in neuroendocrine neoplasms from many other sites. The lack of …

The role of DLLs in cancer: a novel therapeutic target

MX Xiu, YM Liu, B Kuang - OncoTargets and therapy, 2020 - Taylor & Francis
… vasculature and tumor immunity, which play different roles in cancer progression. DLLs … as
anti-cancer therapeutics. In this review, we discuss the role of DLLs in cancer and summarize …

[HTML][HTML] Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms

B Smolkova, A Kataki, J Earl, I Ruz-Caracuel… - Critical Reviews in …, 2022 - Elsevier
… Grading and correct histological diagnosis are important regarding pNEN treatment strategy.
Grading based on the Ki-67 index has been proven to be the most reliable factor in the …

Gastroenteropancreatic neuroendocrine neoplasms G3: Novel insights and unmet needs

M Shi, Z Fan, J Xu, J Yang, Y Li, C Gao, P Su… - … )-Reviews on Cancer, 2021 - Elsevier
… gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) can be divided into well
differentiated neuroendocrine tumors G3 (NETs G3) and poorly differentiated neuroendocrine

Management of adrenocortical carcinoma: are we making progress?

B Kiesewetter, P Riss, C Scheuba… - Therapeutic …, 2021 - journals.sagepub.com
novel therapeutic strategies, including targeted therapies … evolvement of novel technologies
and molecular markers. Aubert … and everolimus for pancreatic neuroendocrine tumors, and …

Breast cancer heterogeneity and response to novel therapeutics

M Baliu-Piqué, A Pandiella, A Ocana - Cancers, 2020 - mdpi.com
cancer is a heterogeneous disease that is driven by genetic, … article we review genetic and
non-genetic causes of tumor … heterogeneity has on resistance to therapy. We will provide …

Targeting citrate as a novel therapeutic strategy in cancer treatment

L Huang, C Wang, H Xu, G Peng - … Acta (BBA)-Reviews on Cancer, 2020 - Elsevier
… of citrate in the regulation of both tumor cells and immune cells, the underlying molecular
mechanisms, and the potential of using citrate as a novel therapeutic agent and a biomarker. …

Current and novel therapeutic opportunities for systemic therapy in biliary cancer

JJG Marin, MG Prete, A Lamarca, S Tavolari… - … journal of cancer, 2020 - nature.com
therapies, active research avenues explore the development of novel therapeutics that target
the crosstalk between cancer and … In this review, we discuss the therapeutic opportunities …

[HTML][HTML] Gastroenteropancreatic neuroendocrine neoplasms: A clinical snapshot

CJ Fernandez, M Agarwal, B Pottakkat… - World journal of …, 2021 - ncbi.nlm.nih.gov
… 177 lutetium-DOTATATE will target the tumor cells by emitting β and γ radiations, forming
the basis for the novel treatment known as peptide receptor radionuclide therapy or PRRT[78]. …