… The introduction of monoclonal antibodies targeting tumour necrosis factor-α (TNF) in the …
guidance provided on the selection of alternative molecules. There is also some evidence …

… cell signaling molecules during inflammation and UC … diseases (IBD) can be classified into
anti- Tumor necrosis factor (TNF… -α antibodies bind to TNF-α, blocking its harmful effects, such …

… option as antibodies are specific for a given therapeutic molecule (… mechanisms of
action, this option is not commonly used and may be reserved for certain patients with extra-intestinal …

… due to the variations in the molecular structure. Hence, the … inhibitor OR TNF inhibitor OR
anti-tumor necrosis factor OR … antibodies penetrate the inflamed sites of the colon in vivo [94]…

… Antibodies have provided invaluable treatment options for … to modulate the activity of their
target molecules. Immunotherapy, … necrosis factor alpha is considered a major player in driving …

… , tumor necrosis factor-alpha (TNF-α) is a central inflammatory … peptides and their effects on
the inflamed intestinal barrier in … mechanisms of action of molecules with anti-TNF-α activity …

… It is one of the etiopathogenic forms of inflammatory bowel disease (IBD), a group of … Biologic
(or biotechnologic) drugs are large molecules (often monoclonal antibodies) produced from …

Background: A total of 15% to 40% of adult inflammatory bowel disease (IBD) patients are
obese. The influence of obesity on anti-tumor necrosis factor-α (anti-TNF-α) treatment in IBD …

… Anti- tumor Necrosis Factor (anti-TNF) agents are the … or of multiple switches among different
molecules are lacking. … monoclonal antibodies used for immune-mediated inflammatory …

… patients with inflammatory bowel disease do not respond to anti-tumour necrosis factor (anti-…
[87] characterised molecular mechanisms that were associated with endoscopic resistance …