The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies
… inflammatory diseases with upregulated levels of TNF-α, a number of therapeutic antibodies
… Despite their clinical success, the mode-of-action of different antibody formats with regard to …
… Despite their clinical success, the mode-of-action of different antibody formats with regard to …
BMI is important in predicting the loss of response in inflammatory bowel disease patients on tumour necrosis factor-α inhibitors
W Chuck, BF Shadbolt, F Nordin… - European Journal of …, 2022 - journals.lww.com
… chimeric antibody and adalimumab a recombinant humanized IgG antibody against TNF-α. …
adalimumab in our study can be attributed to the mode of drug administration and regimen, …
adalimumab in our study can be attributed to the mode of drug administration and regimen, …
Cytokines in inflammatory bowel diseases–update 2020
M Leppkes, MF Neurath - Pharmacological Research, 2020 - Elsevier
… activity by anti-tumor necrosis factor (TNF)-agents leads to the development of anti-nuclear
antibodies … of publications deciphering the molecular and systemic interconnections of these …
antibodies … of publications deciphering the molecular and systemic interconnections of these …
Inflammatory Bowel Disease as a Paradoxical Reaction to Anti-TNF-α Treatment—A Review
… Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory … cytokines, and the expression of
adhesion molecules [1]. TNF-α … IFX is a monoclonal antibody to TNFα made up of a chimeric …
adhesion molecules [1]. TNF-α … IFX is a monoclonal antibody to TNFα made up of a chimeric …
Outcomes of children with inflammatory bowel disease who develop anti-tumour necrosis factor-induced skin reactions
MT Dolinger, P Rolfes, E Spencer… - Journal of Crohn's …, 2022 - academic.oup.com
… Anti-tumour necrosis factor [anti-TNF] induced skin reactions are common adverse events
in paediatric inflammatory bowel disease [IBD]. We aimed to report on outcomes of children …
in paediatric inflammatory bowel disease [IBD]. We aimed to report on outcomes of children …
[HTML][HTML] Updates on conventional therapies for inflammatory bowel diseases: 5-aminosalicylates, corticosteroids, immunomodulators, and anti-TNF-α
J Park, JH Cheon - The Korean journal of internal medicine, 2022 - ncbi.nlm.nih.gov
… anti-tumor necrosis factor-α … molecules for treating IBDs, conventional therapies including
5-aminosalicylates (5-ASA), corticosteroids, immunomodulators, and anti-tumor necrosis factor-…
5-aminosalicylates (5-ASA), corticosteroids, immunomodulators, and anti-tumor necrosis factor-…
Anti-TNF-α treatment reduces the baseline procoagulant imbalance of patients with inflammatory bowel diseases
A Tripodi, L Spina, LF Pisani, L Padovan… - Inflammatory Bowel …, 2021 - academic.oup.com
… inflammation may be a triggering factor. We hypothesized that strong inflammation inhibitors
(eg, anti-tumor necrosis factor… and the possible modifications of many other molecules after …
(eg, anti-tumor necrosis factor… and the possible modifications of many other molecules after …
Tumor necrosis factor receptor 2 (TNFR2): an emerging target in cancer therapy
J Medler, K Kucka, H Wajant - Cancers, 2022 - mdpi.com
… antibody Y9 with its assumed FcγR-dependent agonism and a PDL1 blocking antibody resulted
in superior anti-tumor activity… by FcγR-bound antibody molecules) is not fully clear in this …
in superior anti-tumor activity… by FcγR-bound antibody molecules) is not fully clear in this …
[HTML][HTML] Positioning biologics in the treatment of IBD: A practical guide–Which mechanism of action for whom?
P Juillerat, MM Grueber, R Ruetsch, G Santi… - Current research in …, 2022 - Elsevier
… of inflammatory bowel diseases (IBD). Monoclonal antibodies against tumor necrosis factor
… small molecules and a new generation of antibodies which are more focused on the key …
… small molecules and a new generation of antibodies which are more focused on the key …
Small molecule drugs in the treatment of inflammatory bowel diseases: which one, when and why?–a systematic review
… anti-tumor necrosis factor α agents have contributed to the development of new molecules
with different mechanisms of action … speed of onset of action: monoclonal antibodies that are …
with different mechanisms of action … speed of onset of action: monoclonal antibodies that are …