Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management

JS Knight, DW Branch, TL Ortel - bmj, 2023 - bmj.com
antiphospholipid syndrome was first recognized in patients with lupus, the stand alone
presentation of antiphospholipid syndrome … Studies of antiphospholipid syndrome pathogenesis

The pathophysiology of the antiphospholipid syndrome: a perspective from the blood coagulation system

R Arreola-Diaz, A Majluf-Cruz… - Clinical and Applied …, 2022 - journals.sagepub.com
antiphospholipid syndrome (… antiphospholipid antibodies such as lupus anticoagulant,
anti-β-2-glycoprotein 1, and/or anticardiolipin antibodies. In the obstetrical APS, antiphospholipid

Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome

JS Knight, Y Kanthi - Seminars in immunopathology, 2022 - Springer
… also key drivers of APS pathophysiology. Thrombotic events in … This review will highlight
known pathogenic factors in APS … a barrier that selectively permits molecular and cellular transit …

Pathogenesis, diagnosis and management of obstetric antiphospholipid syndrome: a comprehensive review

J Alijotas-Reig, E Esteve-Valverde… - Journal of clinical …, 2022 - mdpi.com
… injury by two pathogenic mechanisms: (i) complexes of TF with FVIIa and/or FVIIa-FXa
induce the production of TNF-α, interleukins and adhesion molecules by cleaving protease-…

Antiphospholipid syndrome: a clinical perspective

Y Zuo, H Shi, C Li, JS Knight - Chinese Medical Journal, 2020 - mednexus.org
… [20,21] As the pathogenesis of APS has been reviewed in … that may advance our understanding
of APS pathogenesis. … inflammatory molecules (intercellular cell adhesion molecule […

Antiphospholipid syndrome

LR Sammaritano - Best Practice & Research Clinical Rheumatology, 2020 - Elsevier
Antiphospholipid syndrome is an autoimmune systemic disorder characterized by arterial,
venous, or small vessel thrombosis and/or recurrent early pregnancy loss, fetal loss, or …

The weight of IgA anti-β2glycoprotein I in the antiphospholipid syndrome pathogenesis: closing the gap of seronegative antiphospholipid syndrome

O Cabrera-Marante, E Rodríguez de Frías… - … Journal of Molecular …, 2020 - mdpi.com
antiphospholipid syndrome (APS) is still controversial and a matter of active debate. The
relevance of the IgA aB2GP1 isotype in the pathophysiology … , we summarize the molecular and …

An update on antiphospholipid syndrome

E Xourgia, MG Tektonidou - Current Rheumatology Reports, 2021 - Springer
Antiphospholipid syndrome (APS) is a rare and complex autoimmune disorder … thrombosis
and pregnancy complications in the presence of antiphospholipid antibodies (aPL), including …

Management of antiphospholipid syndrome

A Ghembaza, D Saadoun - Biomedicines, 2020 - mdpi.com
Antiphospholipid syndrome (APS), is an acquired autoimmune disorder characterised by
thrombosis, pregnancy morbidity, and the presence of antiphospholipid antibodies (aPL). …

The antiphospholipid syndrome–often overlooked cause of vascular occlusions?

E Svenungsson, A Antovic - Journal of Internal Medicine, 2020 - Wiley Online Library
… This review aims to summarize the present knowledge on the history, pathogenesis, clinical
… GPI molecule, that is the nonphospholipid binding tail of the molecule, are more pathogenic