… adaptation through their participation in multiple signaling … with the jun N-terminal kinase
(JNK) pathway, in parallel and … a nexus that unifies different signaling pathways and cellular …

… , as well as adaptation to metabolic stress such as glucose deprivation and hypoxia [145] .
… lipid metabolic reprogramming. The interconnectedness of signaling pathways that control …

… of the targeted molecule, allowing cell survival. In normal cells, signalling … from adaptive
signalling rewiring can be targeted by blocking bypass pathways or inhibiting redundant kinase …

… by the MAPK pathway, leading to receptor tyrosine kinase (RTK)-… SHP2 inhibition can
abrogate adaptive feedback reactivation of RAS pathway signaling following KRAS G12C inhibition…

… protein kinase that mediates the PI3K signaling pathway. … matrix structure, immune response,
angiogenesis, metastasis … the main adaptive changes in tumor metabolic reprogramming …

… -activated protein kinase (AMPK) signaling pathways that involve cell metabolism reprogramming
in cancer … Ca 2+ signaling might play a crucial role in the adaptive resistance to EGFR …

… phosphate pathway, adaptive mitochondrial reprogramming, … of the tumor-driving signaling
pathway. General mechanisms, … Sorafenib is a tyrosine kinase inhibitor. Metabolism in …

… the master molecular regulators in the adaptive responses to … role played by the kinase
mammalian target of rapamycin (… and discovered the signaling pathways involved in the cancer …

… Nevertheless, the involvement of acidic-adapted melanoma cells in … We have discussed
below some of the signaling pathways … -3-kinase/Akt pathway is a crucial intracellular signaling …

… It has been proposed previously that RAS/MEK signaling … that targeted inhibition of
oncogenic signaling could reverse … into the adaptation processes following kinase inhibition but …