Multiancestry genome-wide association study of aortic stenosis identifies multiple novel loci in the Million Veteran Program

AM Small, GM Peloso, J Linefsky, J Aragam… - Circulation, 2023 - Am Heart Assoc
… In summary, we performed a large, multiancestry GWAS of CAS and identified 14 unique …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated

Multi-ancestry Genome-wide Association Study of Varicose Veins Reveals Polygenic Architecture, Genetic Overlap with Arterial and Venous Disease, and Novel …

MG Levin, JE Huffman, A Verma, KA Sullivan… - medRxiv, 2022 - medrxiv.org
… We also found loci associated with varicose veins and clusters of circulating metabolites (3 …
genome wide association study of varicose veins to-date, we identify novel genetic risk loci

Multi-ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke

L Ibanez, L Heitsch, C Carrera, FHG Farias… - Brain, 2022 - academic.oup.com
genome-wide association studies (GWAS), mostly in populations of European descent, have
identified numerous loci associated … novel loci, bringing the total stroke risk loci to 32. Many …

[HTML][HTML] Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.

L Ibanez, L Heitsch, C Carrera, FHG Farias, R Dhar… - medRxiv, 2020 - ncbi.nlm.nih.gov
genome wide association studies (GWAS), mostly in populations of European descent, have
identified numerous loci associated … novel loci, bringing the total stroke risk loci to 32. Many …

Polygenic score informed by genome-wide association studies of multiple ancestries and related traits improves risk prediction for coronary artery disease

…, PT Ellinor, Genes & Health Research Team… - MedRxiv, 2023 - medrxiv.org
… training analysis, with 32 scores significantly contributing to … mixing weights to yield
multi-ancestry scores predicting CAD … or undergoing revascularization, identified as subjects with …

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

S Koyama, K Ito, C Terao, M Akiyama, M Horikoshi… - Nature …, 2020 - nature.com
… a large-scale genome-wide association study of 168,228 … accumulation disease,
cerebrotendinous xanthomatosis 32 . … Cluster 2 harbors the loci associated with glycemic traits. …

Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels

C Sarnowski, M Ghanbari, JC Bis, M Logue… - Communications …, 2022 - nature.com
… Several studies also suggest a role for ADAMTS12 in stroke 32,33 . … In conclusion, our
large multi-ancestry meta-analysis identified new genetic variants and loci associated with …

Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries

I Surakka, KH Wu, W Hornsby, BN Wolford, F Shen… - Cell genomics, 2023 - cell.com
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated
with stroke and … subjects identifies 32 loci associated with stroke and stroke subtypes. …

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

…, Genes & Health Research Team; the Million Veteran … - Nature Medicine, 2023 - nature.com
… data derived from genome-wide association studies (GWASs)—… polygenic score (GPS)
training analysis, with 32 scores … undergoing revascularization, identified as subjects with at least …

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

…, Lifelines Cohort Study Boezen H. Marike 10 … - Nature …, 2021 - nature.com
genome-wide association study (GWAS) of serum activities of liver enzymes 11 on ~60,000
individuals of European ancestry identified 44 genetic loci … 2006 and 2010 32 . We included …