… Multifocal prostate cancers typically have one dominant focus, or index tumor, and one or
more smaller and secondary malignant foci [22]. One study reported that 88% of radical …

Context Studies characterising genomic changes in prostate cancer (PCa) during natural
progression have greatly increased our understanding of the disease. A better understanding …

… tumor foci in different anatomical zones of the prostate is … The impact of tumor multifocality in
PCa prognosis has been … MF and UF prostatic carcinomas may be biologically different, with …

… To determine the prevalence of multiparametric magnetic resonance imaging (mpMRI)-detected
and targeted biopsy-confirmed multifocal and unifocal prostate cancer (PCa) among …

… Prostate cancer has a … prostate cancer patient care and in the research field. The power of
deep sequencing has provided cistromic and transcriptomic knowledge of prostate cancer that …

… hallmark of cancer, is frequently observed in the prostate, though its contribution to
prostate cancer risks and outcomes is not fully understood. Prostate cancer is biologically and …

… In such discordant cases, the largest tumor may not be of biological significance and the …
compared their prognosis with that of concordant cases. This study will have implications for …

… The experiences to date available in literature mainly use magnetic resonance as imaging
underlayer and are focused on the prediction of biological aggressiveness of prostate cancer, …

… prostate cancer has long been known to be multifocal, but … This suggests, that a prostate
gland can harbor multiple separate … show distinct molecular alterations and biological behavior …

Background and Objectives: Significant numbers of prostate cancer (PCa) patients experience
tumour upgrading and upstaging between prostate biopsy and radical prostatectomy (RP) …