… The protein kinase CK2 phosphorylates a wide range of … CK2 inhibitor is dependent on
p53, which is regarded as a … increased dependency on Bcl2 for cell survival. Furthermore, …

… a different perspective about the actual reliance of cancer cells on CK2. Collectively taken, …
cell line resulted in a significant decrease in cell viability [18]; in multiple myeloma cell lines, …

… Protein kinase CK2 inhibition has long been considered as … factors critically involved in
cell survival, proliferation, … rely on the unique/distinctive characteristics of its main target …

… Since protein kinases play dominant roles in the regulation … , which will likely rely on p53
activity, can be hypothetically … in multiple myeloma (MM), which is a cancer of plasma cells. …

… that CK2 kinase supports CML cell viability even in cells with … This suggests that in resistant
cells, CK2 activity is dependent … Pharmacological inhibition of protein kinase CK2 reverts the …

… underlying BTZ resistance depends upon studies using the … as an adaptor to load protein
kinases to the Hsp90 complex, … to guide the stabilization and activation of protein kinases 5,6,7 . …

… with respect to cell survival, growth and metastasis [18]. … Castelman’2 disease or multiple
myeloma (test IDs: NCT00891280… This is based on the fact that (i) CK2 phosphorylates LPIN1 at …

… that CK2 sustains tumor progression in multiple myeloma (… MCL cell survival through the
activation of active BCR-linked … anti-apoptotic effect of CK2 in MCL might depend on its role on …

… are mostly restricted to the bone marrow and heavily depend … on cell viability against eight
different human myeloma cell … protein kinases (ERK) 1/2 and c-Jun N-terminal kinase (JNK). …

… cells survival and chemosensitivity, reinforcing the rationale behind the pharmacologic
blockade of protein kinase CK2 for … KEA2 is based on an integrative database of kinase-substrate …