[HTML][HTML] Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy
Y Wang, N Vandewalle, K De Veirman… - Cell Communication …, 2024 - ncbi.nlm.nih.gov
… TOR is an evolutionarily conserved Ser/Thr-protein kinase that exists in two … the relief of the
feedback inhibition, leading to constitutive active PI3K/TORC2/AKT signaling and cell survival…
feedback inhibition, leading to constitutive active PI3K/TORC2/AKT signaling and cell survival…
[HTML][HTML] FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
D Kanaoka, M Yamada, H Yokoyama, S Nishino… - Cancer Research …, 2024 - AACR
… multiple myeloma, erythema nodosum leprosum, and POEMS (polyneuropathy, organomegaly,
endocrinopathy, M-protein, … E, Cell viability (%) of Z-138, OCI-Ly3, and MOLM-13 cells …
endocrinopathy, M-protein, … E, Cell viability (%) of Z-138, OCI-Ly3, and MOLM-13 cells …
[PDF][PDF] THE ROLES OF SERINE/THREONINE KINASE CK2 AND INTERLEUKIN-7/INTERLEUKIN-7 RECEPTOR IN CANCER PATHOPHYSIOLOGY
GÇ DİNÇEL - MULTIDISCIPLINARY APPROACH IN MEDICAL …, 2023 - iksadyayinevi.com
… Multiple myeloma cell survival relies on high activity of protein kinase CK2. Blood , 108 (5),
1698–1707. Qu, H., Zou, Z., Pan, Z., Zhang, T., Deng, N., Chen, G., & Wang, Z.…
1698–1707. Qu, H., Zou, Z., Pan, Z., Zhang, T., Deng, N., Chen, G., & Wang, Z.…
Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy
MF McCarty, SI Assanga, LL Lujan - Medical hypotheses, 2020 - Elsevier
… -threonine kinase CK2, which targets over 300 cellular proteins, is … chaperoning activity for
a broad range of protein kinases, … multiple myeloma cells through targeting the trinity of CK2, …
a broad range of protein kinases, … multiple myeloma cells through targeting the trinity of CK2, …
New responsibilities for aged kinases in B‐lymphomas
F Piazza, S Manni, A Arjomand, A Visentin… - Hematological …, 2020 - Wiley Online Library
… instrumental for cell survival and proliferation and its activity is … Other low-grade NHL also
depends for their survival upon … , protein kinases CK1, CK2, and glycogen synthase kinase 3 (…
depends for their survival upon … , protein kinases CK1, CK2, and glycogen synthase kinase 3 (…
[HTML][HTML] CK2β-regulated signaling controls B cell differentiation and function
L Quotti Tubi, E Mandato, S Canovas Nunes… - Frontiers in …, 2023 - frontiersin.org
… post-GC B cells and rely on CK2 for their survival, we sought to … Since CX-4945 could
affect cell viability and growth, we … Protein kinase CK2 in health and disease: Protein kinase …
affect cell viability and growth, we … Protein kinase CK2 in health and disease: Protein kinase …
[PDF][PDF] Casein kinase 2 (CK2) is a bona fide member of the yeast SSU processome and links ribosome assembly to cell growth
JJL Cluff, E Poole, JM Charette - 2021 - irbu.arcabc.ca
… This is especially true for the protein kinase CK2, historically known as casein kinase II. …
loss of CK2 kinase activity, we suggest a new model. We propose that the mechanism of CK2 …
loss of CK2 kinase activity, we suggest a new model. We propose that the mechanism of CK2 …
[HTML][HTML] Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells
VE Hermosilla, L Gyenis, AJ Rabalski, ME Armijo… - Cell death & …, 2024 - nature.com
… cell death [6], we reasoned that the downregulation of SALL2 by CK2 may impact cell survival
in cancer cells. … and T778 phosphorylation depend on CK2 activity but only occurs in cells, …
in cancer cells. … and T778 phosphorylation depend on CK2 activity but only occurs in cells, …
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2
ZW Davis-Gilbert, A Krämer, JE Dunford… - ACS medicinal …, 2023 - ACS Publications
… ability to engage the target kinase CK2 in cells (Table 1). Most … Whether inhibition of CK2
impacts cell survival and is a suitable … The authors point out that they rely on a WST-1 assay for …
impacts cell survival and is a suitable … The authors point out that they rely on a WST-1 assay for …
Damage Mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia
I Vélez-Rodríguez… - Journal of …, 2024 - geographical.go2journals.com
… CK2 activity does not rely on small molecules involved in second-messenger … growth
and proliferation by controlling the cell cycle. The protein kinase CK2 plays a crucial role in …
and proliferation by controlling the cell cycle. The protein kinase CK2 plays a crucial role in …