Exploiting DNA Ligase III addiction of multiple myeloma by flavonoid Rhamnetin
… protein was performed by Saturation Transfer Difference (STD)—nuclear magnetic resonance
(NMR) experiments. Cell viability was analyzed by Cell … depends on DDR signaling [7]. …
(NMR) experiments. Cell viability was analyzed by Cell … depends on DDR signaling [7]. …
TTT (Tel2-Tti1-Tti2) Complex, the co-chaperone of PIKKs and a potential target for cancer chemotherapy
S Bhadra, Y Xu - International Journal of Molecular Sciences, 2023 - mdpi.com
… complex is essential for cell viability and highly conserved in … related to lipid kinase but
possess protein kinase activities [4,… in a manner that depends on Tel2 phosphorylation by CK2. …
possess protein kinase activities [4,… in a manner that depends on Tel2 phosphorylation by CK2. …
[HTML][HTML] Casein Kinase 1α—A Target for Prostate Cancer Therapy?
E Lishman-Walker, K Coffey - Cancers, 2024 - mdpi.com
… its activity include Checkpoint Kinase 1 and Protein Kinase A [… This phosphorylation is
dependent on E221, E225, and … p53, thereby decreasing multiple myeloma cell survival [69]. …
dependent on E221, E225, and … p53, thereby decreasing multiple myeloma cell survival [69]. …
The role of exosomes in the progression and therapeutic resistance of hematological malignancies
H Wang, Y You, X Zhu - Frontiers in Oncology, 2022 - frontiersin.org
… The apoptotic ability of cells depends to a large extent on the … cells survival in vitro and
tumor growth of leukemia cells in … cells with DRB (a selective inhibitor of protein kinase CK2) …
tumor growth of leukemia cells in … cells with DRB (a selective inhibitor of protein kinase CK2) …
Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation
J Lázaro-Navarro, HJ Pimentel-Gutiérrez… - Blood …, 2021 - ashpublications.org
… phase 1/2 clinical trials for solid tumors and multiple myeloma. … Cell viability after treatment
with a minimally effective dose of … ALL cells depend on antiapoptotic signaling pathways for …
with a minimally effective dose of … ALL cells depend on antiapoptotic signaling pathways for …
An Intriguing Purview on the Design of Macrocyclic Inhibitors for Unexplored Protein Kinases through Their Binding Site Comparison
SP Bhujbal, JM Hah - Pharmaceuticals, 2023 - mdpi.com
… that depend on the association with a cyclin regulatory … Protein kinase CK2 is an extensively
conserved and pleiotropic … (JNK) family, which plays a crucial role in regulating cell survival …
conserved and pleiotropic … (JNK) family, which plays a crucial role in regulating cell survival …
[HTML][HTML] CK2β Regulates Hematopoietic Stem Cell Biology and Erythropoiesis
… -Thr kinase CK2 plays important roles in sustaining cell survival and … Protein kinase CK2 is
a Ser/Thr kinase constituted by a … cells, 22 , 23 multiple myeloma 24–26 and non-Hodgkin B …
a Ser/Thr kinase constituted by a … cells, 22 , 23 multiple myeloma 24–26 and non-Hodgkin B …
The Effect of Casein Kinase 2 Inhibition on three Leukemic Cell Lines
… leukaemia, multiple myeloma, and different types of lymphoma [18]. We also confirmed …
Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by …
Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by …
Natural products in precision oncology: Plant-based small molecule inhibitors of protein kinases for cancer chemoprevention
HJ Thompson, T Lutsiv - Nutrients, 2023 - mdpi.com
… The conceptual organizational structure that we propose is based on a redeployment of the
… a botanical evolutionary tree identifying protein kinase inhibitors is based on the premise that …
… a botanical evolutionary tree identifying protein kinase inhibitors is based on the premise that …
Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects
… Further, they are involved in the transcriptional activation of cell survival and cell cycle …
myelogenous leukemia, prostate cancer lymphoma, or multiple myeloma [27]. Therefore, Non-ATP …
myelogenous leukemia, prostate cancer lymphoma, or multiple myeloma [27]. Therefore, Non-ATP …