CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway

J Fan, G Tong, X Chen, S Li, Y Yu, S Zhu… - British journal of …, 2023 - Wiley Online Library
… hepatic stellate cells (HSCs). The protein kinase CK2 is a pro-survival kinase overexpressed
in … the regulation pattern of CK2 may depend on the disease triggers and affected tissues or …

The Use of High Quality Chemical Tools to Rescue TBK1 Function and Identify Novel ATP-Competitive Targets in ALS

A Axtman, T Durcan, L Beitel, S Lpine… - 2022 - apps.dtic.mil
… Since we rely heavily on Ukrainian companies Enamine and … ’s sarcoma and multiple
myeloma cell lines and found they … clinical stage inhibitor of protein kinase CK2 for the treatment …

[HTML][HTML] Complex roles of cAMP–PKA–CREB signaling in cancer

H Zhang, Q Kong, J Wang, Y Jiang, H Hua - Experimental hematology & …, 2020 - Springer
… are regulated by various protein kinases and phosphatases, … The concentration of
intracellular cAMP depends on the … /2 and CREB mediate cell survival in oxidative stress [85]. …

[HTML][HTML] Interplay between proteasome inhibitors and NF-κB pathway in leukemia and lymphoma: a comprehensive review on challenges ahead of proteasome …

M Pakjoo, SE Ahmadi, M Zahedi, N Jaafari… - Cell Communication and …, 2024 - Springer
Proteins produced by cancer cells promote cell survival, … its precursor protein p100 also relies
on proteasome activity; … 3-kinase and serine/threonine protein kinase B (PI3K/Akt pathways…

[HTML][HTML] Synthesis of Novel Acyl Derivatives of 3-(4,5,6,7-Tetrabromo-1H-benzimidazol-1-yl)propan-1-ols—Intracellular TBBi-Based CK2 Inhibitors with Proapoptotic …

K Chojnacki, P Wińska, O Karatsai… - International Journal of …, 2021 - mdpi.com
protein kinase CK2 as well as the induction of apoptosis in both cell lines by the newly
synthesized active … the idea that CK2 kinase is vital factor for breast cancer cell survival and an …

JNK signaling as a target for anticancer therapy

KS Abdelrahman, HA Hassan, SA Abdel-Aziz… - Pharmacological …, 2021 - Springer
… The JNKs are members of mitogen-activated protein kinases (… , macrophages, cell proliferation,
differentiation, survival, and … contributed in cell survival but JNK2 exhibited cell death and …

Targeting protein kinases for anti-glioma treatment

E Pucko, R Ostrowski - Folia Neuropathologica, 2020 - termedia.pl
… Their role in glial tumours may rely on regulating cell survival, … Cell-permeable dual inhibitors
of protein kinases CK2 and PIM-1: structural features and pharmacological potential. Cell

A serine/threonine protein PIM kinase as a biomarker of cancer and a target for anti-tumor therapy

NK Panchal, EP Sabina - Life sciences, 2020 - Elsevier
Protein kinases are especially known for promoting cell … , PIM kinases possess pro-survival
activity which depends on … primary cells, persuading impairment of PIM-mediated cell survival

Targeting death-associated protein kinases for treatment of human diseases: recent advances and future directions

L Zhang, B Luo, Y Lu, Y Chen - Journal of Medicinal Chemistry, 2023 - ACS Publications
… substrate MLC, indicating that CHP negatively regulates DRAK2 activity (80) (Figure 2C).
Typically, the inhibitory activity of CHP is dependent on Ca 2+ levels, but interestingly the …

[HTML][HTML] CIGB-300-Regulated proteome reveals common and tailored response patterns of AML Cells to CK2 inhibition

M Rosales, A Rodríguez-Ulloa, GV Pérez… - Frontiers in molecular …, 2022 - frontiersin.org
Protein kinase CK2 is a highly pleiotropic and ubiquitously expressed Ser/Thr kinase with
… pathways critical for hematopoietic cell survival and function, and its high expression and …