I-TASSER-MTD: a deep-learning-based platform for multi-domain protein structure and function prediction

X Zhou, W Zheng, Y Li, R Pearce, C Zhang, EW Bell… - Nature …, 2022 - nature.com
… the multi-domain structure assembly simulations. I-TASSER-MTD is built on I-TASSER but
substantially extends its ability and accuracy in modeling large multi-domain protein structures

Foldseek: fast and accurate protein structure search

M van Kempen, SS Kim, C Tumescheit, M Mirdita… - Biorxiv, 2022 - biorxiv.org
… This illustrates that 3D aligners as TM-align may overlook homologous structures that are
not … domain orientations and excels at detecting homologous multi-domain structures [12]. …

DeepMSA: constructing deep multiple sequence alignment to improve contact prediction and fold-recognition for distant-homology proteins

C Zhang, W Zheng, SM Mortuza, Y Li, Y Zhang - Bioinformatics, 2020 - academic.oup.com
… To more objectively assess the quality of MSA builders, below we apply these MSAs to
three protein structure modeling experiments, ie residue contact prediction, SS prediction and …

[图书][B] Protein structure modeling with MODELLER

B Webb, A Sali - 2021 - Springer
… with the known behaviors of protein structures (for example by combining multiple short …
However, MODELLER can also generate models of complexes of multiple proteins if templates …

[HTML][HTML] Toward the solution of the protein structure prediction problem

R Pearce, Y Zhang - Journal of Biological Chemistry, 2021 - ASBMB
… a protein structure, the growth in the number of solved protein structures has lagged far
behind the accumulation of protein … So far, the structures of approximately 0.18 million proteins

Deep learning techniques have significantly impacted protein structure prediction and protein design

R Pearce, Y Zhang - Current opinion in structural biology, 2021 - Elsevier
… In addition to the high accuracy of model training enabled by multi-layer neural networks [1],
another important advantage of deep learning is its ability to predict multiple structural

Pairwise versus multiple global network alignment

V Vijayan, S Gu, ET Krebs, L Meng, T Milenković - IEEE Access, 2020 - ieeexplore.ieee.org
… New protein function prediction for multiple alignments. Here, we introduce a new … protein
GO-term associations from a multiple alignment. First, for each node group Ci in the alignment, …

US-align: universal structure alignments of proteins, nucleic acids, and macromolecular complexes

C Zhang, M Shine, AM Pyle, Y Zhang - Nature methods, 2022 - nature.com
… The core idea of US-align is built on the construction of multiple heuristic alignments that
cover … a–d, Performance of oligomeric protein structure alignment by US-align, MM-align and …

DALI and the persistence of protein shape

L Holm - Protein Science, 2020 - Wiley Online Library
… DALI to compare a new structure against previously known protein structures. If significant
… content can be missed (eg, chlorophyll-binding protein). Multiple structural alignment seeks …

Protein language-model embeddings for fast, accurate, and alignment-free protein structure prediction

K Weissenow, M Heinzinger, B Rost - Structure, 2022 - cell.com
… Advanced protein structure prediction requires evolutionary information from multiple
sequence alignments (MSAs) from evolutionary couplings that are not always available. Artificial …