Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease

L Dwomoh, GS Tejeda, AB Tobin - Neuronal Signaling, 2022 - portlandpress.com
Alzheimer’s disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease. …

[HTML][HTML] Fine tuning muscarinic acetylcholine receptor signaling through allostery and bias

ET Van der Westhuizen, KHC Choy, C Valant… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease is a neurodegenerative disease that … -β protein plaques in neurons and
hyperphosphorylation of … in long-term depression in the prefrontal cortex and the potential for …

Integrated phylogeny of the human brain and pathobiology of Alzheimer's disease: A unifying hypothesis

SV Ovsepian, VB O'Leary, C Hoschl, L Zaborszky - Neuroscience letters, 2021 - Elsevier
… of the prefrontal cortex and parietal association areas display the … of neuronal precursors
supplying neurons to expanding … [91], activation of M1 and M3 muscarinic AChR suppresses the …

Distribution of nicotinic receptors in the CNS

EK Perry - CNS neurotransmitters and neuromodulators, 2020 - taylorfrancis.com
… loss of neurons positive for the nicotinic monoclonal antibody WF6 in the human frontal cortex
… , A., Human cortical neurons contain both nicotinic and muscarinic acetylcholine receptors: …

Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review

M Golmohammadi, M Mahmoudian… - Fundamental & …, 2024 - Wiley Online Library
… The initial stage involves the accumulation of granular tau oligomers in the frontal cortex, …
and muscarinic acetylcholine receptors due to marked degeneration of cholinergic neurons

Potential Therapeutics from Ayurveda, Siddha, and Homeopathic Medical System for Alzheimer's Disease

S Chandrani, A Justin Thenmozhi - Nutraceuticals for Alzheimer's Disease …, 2023 - Springer
… The primary neuropathology of Alzheimer’s disease is … neurons, mostly affecting the
temporoparietal and frontal … of age-related loss of muscarinic cholinoceptors and adrenoceptors, …

[HTML][HTML] … new role for matrix metalloproteinase-3 in the NGF metabolic pathway: proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's …

R Pentz, MF Iulita, M Mikutra-Cencora… - … of disease, 2021 - Elsevier
… (or non-specific neuronal depolarization), … Alzheimer's disease. (A) Levels of MMP-3 mRNA,
(B) proMMP-3 and (C) MMP-3 protein were assessed in dorsolateral/medial prefrontal cortex

… of acetylcholine and gabaergic inhibitory transmission in seizure pattern generation in neural networks integrating the neocortex, hippocampus, basal ganglia, and …

IG Silkis - Neurochemical Journal, 2020 - Springer
neurons are also present in the medial prefrontal cortex (PFC… nicotinic receptors and muscarinic
M1 receptors induces LTP of … of thalamic neurons caused by the cholinoreceptor agonist …

[HTML][HTML] Autonomic nervous system and cardiac neuro-signaling pathway modulation in cardiovascular disorders and Alzheimer's disease

A Elia, S Fossati - Frontiers in Physiology, 2023 - frontiersin.org
… , and possibly, Alzheimer’s disease (AD). Here, we explore the physiological and molecular
mechanisms involved in the alterations of the heart neuronal network observed both in …

Pharmacology of acetylcholine and cholinergic receptors

SF Kokaz, PK Deb, SN Abed, A Al-Aboudi… - … in Pharmacology of …, 2020 - Springer
… both hippocampal and prefrontal cortex-dependent forms … muscarinic receptors in the
modulation of neuronal activity and release of neurotransmitter in various brain regions. Muscarinic