… of unknown significance and MSI-high cases were identified in eight cases (8/67, 11%),
and two of these colorectal cancers had multiple POLE mutations, showing an ultramutated …

… We provided a detailed descriptive analysis of mutational profiles as per primary tumour
locations of mCRC and found prognostic relevance for RAS/BRAF-MUT, SMAD4-MUT and MSI-…

… comprehensive genomic profiling of tumour samples from metastatic colorectal cancer (…
microsatellite instability (MSI) status, to characterize tumours according to the tumour mutational …

… Mismatch repair (MMR)/microsatellite instability (MSI) and tumor mutational burden (TMB) …
that integrates MSI and TMB determination for colorectal cancer (CRC) in one single assay. …

… genetic mutations in MSI-high colorectal cancer. Our results demonstrated that among MSI-…
colorectal cancer patients, CIMP-high tumors were associated with specific mutation profiles …

… Colorectal cancer (CRC) is the third most common cancer worldwide. In the past decade,
mismatch repair deficiency (dMMR), manifested as microsatellite instability-high (MSI-H), has …

… (tumor mutational burden, Immunoscore ® , mutational profile) are … with MSI (microsatellite
instability) colorectal cancers (CRCs), … POLE exonucleasic domain mutations are a major …

… (MSI) is a hypermutator phenotype that occurs in tumors with … cancers 2 and observed in
about 15% of colorectal cancer (… The DNA mutation profile and the mRNA expression profile …

… in colorectal cancer (CRC). The status of postoperative plasma mutation of microsatellite
instability (MSI… In this study, we enrolled 30 MSI and 46 microsatellite stability (MSS) CRCs, and …

… CA-CRCs (n = 27) were investigated for microsatellite instability, CpG island … mutational
profiles and signatures for CA-CRC and compare the findings to LS-associated colorectal tumors…