… Frontotemporal lobar degeneration (FTLD) refers to a group of neurodegenerative disorders
… Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to …

… neurodegeneration in FTD caused by GRN mutations (FTD-… caused by GRN and C9orf72
mutations in post-mortem tissue from heavily affected frontal lobe and less affected parietal lobe…

… Frontotemporal lobar degeneration (FTLD) with TDP-43-immunoreactive inclusions (FTLD–…
specific clinical syndromes and genetic mutations which implies different pathomechanisms …

… Progranulin (PGRN) haploinsufficiency from autosomal dominant mutations in the PGRN
gene causes frontotemporal lobar degeneration, which is characterized by cytoplasmic …

… dominant mutations in three genes accounting for the majority of inheritance: progranulin
(… no detectable insoluble tau or tau or ubiquitin positive inclusion bodies detected, are most …

… and progranulin mutations have been associated with behavioral variant as the most
common clinical phenotype, although progranulin mutations … Ubiquitin-positive and tau-negative …

… mutations in the progranulin gene (GRN), which encodes progranulin (PGRN), are a major
cause of frontotemporal … these inclusions were ubiquitin positive (Figure 4C). Although there …

… Encoded by the granulin (GRN, Pgrn) gene in humans, progranulin is widely expressed in
… Pgrn gene mutations resulting in progranulin haploinsufficiency are a common cause of the …

… Frontotemporal lobar degeneration (FTLD) is a complex disease, characterized by progressive
degeneration of frontal and temporal lobes. Mutations in progranulin (GRN) gene have …

… Heterozygous mutations in the gene coding for progranulin (GRN) cause frontotemporal
lobar degeneration (FTLD) while homozygous mutations are linked to neuronal …