LMNA-related muscular dystrophy involving myoblast proliferation and apoptosis through the FOXO1/GADD45A pathway

Y Wu, X Zhu, W Jiang, J Li, H Li, K Zhang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
… -W520R mutation knock-in mouse model, and combined it with … hindlimbs but rarely contacted
one another, a score of 2 indicated … These results demonstrated that blocking the FOXO1/…

Effect of Intramuscular and Intraperitoneal Injections of conjugated MSTN-siRNA-cholesterol on Inhibition of Myostatin Gene expression

M Riasi, S Mozaffari Jovin… - Journal of Cell and …, 2022 - jcmr.um.ac.ir
function of MSTN gene expression in a mouse model. … Histology images were prepared as
previously described. The … in mice used as models for limb-girdle muscular dystrophy 1C was …

[HTML][HTML] Ubiquitin ligases at the heart of skeletal muscle atrophy control

D Peris-Moreno, L Cussonneau, L Combaret, C Polge… - Molecules, 2021 - mdpi.com
… decreased in muscles from Limb-girdle muscular dystrophy (… PTEN improves muscle mass
and function in a mouse model … , that was attributed to decreased expression of myostatin and …

Effects of thermoneutrality on dysferlin-deficient muscular dystrophy

G Donen - 2021 - open.library.ubc.ca
… Current LGMD2B mouse models lack the disease severity … Limb-girdle muscular dystrophy
LGMD2B Limb-girdle … lipids within MD pathology, our lab has shown that by crossing a …

[HTML][HTML] Mathematical model of muscle wasting in cancer cachexia

S Farhang-Sardroodi, KP Wilkie - Journal of Clinical Medicine, 2020 - mdpi.com
… findings suggest that after blocking the myostatin/… blocking the activin type-2 receptor (ActRIIB)
with a soluble decoy receptor (sActRIIB) or a myostatin antibody in several mouse models

[HTML][HTML] Oxidative stress, inflammation and Connexin Hemichannels in muscular dystrophies

A González-Jamett, W Vásquez, G Cifuentes-Riveros… - Biomedicines, 2022 - mdpi.com
muscular dystrophy and limb-girdle muscular dystrophy. These … Histopathologically, MDs
are characterized by degeneration … , a murine model of laminin-deficient muscular dystrophy, …

[HTML][HTML] Identifying Novel Therapeutics And Therapeutic Entry Points For The Treatment Of Duchenne Muscular Dystrophy Through Regulation Of Gene Expression

RM Hightower - 2021 - search.proquest.com
… through, 1) therapeutic treatment of a DMD mouse model … of both limb girdle and Duchenne
muscular dystrophy, which are … Pharmacological blockade of myostatin or the myostatin

How Lama2-deficiency impacts myoblast differentiation in a mouse model for LAMA2-congenital muscular dystrophy

VFL Ribeiro - 2022 - repositorio.ul.pt
… scaffold that (1) attaches the ECM to the cell surface and (2) … , a model for limb-girdle muscular
dystrophy type 2D) – and … dystrophic mouse model, Nfix regulates Mstn (Myostatin gene…

Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease

G Giuliani, M Rosina, A Reggio - The FEBS journal, 2022 - Wiley Online Library
… We will now provide a brief overview on the main murine models (Table 1) … muscular dystrophy
(FSHD), and limb-girdle muscular … Activin A and myostatin [[93]]. As a consequence, FST …

[HTML][HTML] Natural products, PGC-1α, and Duchenne muscular dystrophy

I Suntar, A Sureda, T Belwal, AS Silva, RA Vacca… - … Pharmaceutica Sinica B, 2020 - Elsevier
… (NO) donors and deacetylase inhibitors targeting events downstream of the genetic defect in
both a mouse model of limb girdle muscular dystrophy … stress by H 2 O 2 treatment of mouse