… cell viability and induced cell apoptosis and oxidative stress, which was partly reversed by
NLRX1 upregulation. In conclusion… regulating mitochondrial activity. Li et al. demonstrated that …

… activated mitochondria-related genes including Nlrx1 to … O 2 induces severe cell death through
apoptosis [11], autophagy [… Nlrx1-OE ESCs suppresses oxidative stress, we treated Nlrx1-…

… range of DAMPs released upon tissue injury. Upon IRI, … NLRX1 may act as an inhibitor of
mitochondrial activity and prevents excessive oxidative stress, thereby preventing apoptosis …

… activity following viral or fungal infections of varying tissue … (OXPHOS) experiments (mitochondrial
stress tests) on … of NLRX1 resulted in near complete loss of mitochondrial ATP-linked …

… for NLRX1 in mitochondria function and energetics, we utilized a Seahorse XF Mito Stress
… , SE; Florquin, S.; Leemans, JC NLRX1 Dampens Oxidative Stress and Apoptosis in Tissue …

… TEC apoptosis and oxidative stress. Furthermore, NLRX1 deletion contributes to mitochondrial
… is regarded as a pivotal target in mediating a protective effect against renal tissue injury …

… We focus on the function, structure and disease relevance of … ) bacterial proteins via neuronal
apoptosis inhibitory proteins (… Mitochondrial DNA is a candidate for a downstream mediator …

… Upon encounter of a pathogenic agent or tissue injury, the … effective strategies to dampen
or evade inflammasome … apoptosis resulting from mitochondrial membrane damage in …

… -apoptotic function is hypothesized to be proviral by killing off immune cells (50). Interestingly,
the host can use NLRX1, … The resulting disruption in MAMs dampens the antiviral immune …

… their non-canonical activity. Here we show that … NLRX1 dampens oxidative stress and
apoptosis in tissue injury via control of mitochondrial activity. J Exp Med. 2017; 214 (8): 2405-20. …