NR4A1 promotes oxidative stresses after myocardial ischemia reperfusion injury in aged mice

X Peng, W Wang, W Wang, J Qi - Experimental Gerontology, 2022 - Elsevier
NR4A1 is increased following cardiac microvascular IR injury… In contrast, NR4A1 deletion
preserved cellular energy, suppressed … Similarly, we observed NR4A1 deficiency suppressed

NR4A1 Aggravates Myocardial IschaemiaReperfusion Injury by Inhibiting OPA1-Mediated Mitochondrial Fusion

M Li, Y Hu, H Zhou, Y Chen - Journal of cardiovascular translational …, 2023 - Springer
… In addition, we verified the effect of NR4A1 expression on cell activity by using NR4A1-…
oxidative stress via AMPK/NR4A1 suppression can prevent diabetic cardiomyopathy by …

[HTML][HTML] Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function

ZX Liu, X Han, Y You, GJ Xin, LM Li, JM Gao… - Journal of …, 2024 - Elsevier
ischemia perfusion, which in turn aggravate cardiac injury … effect of SSNX on cardiac
microvascular I/R injury. Our results … cardiac microvascular I/R injury by inhibiting the NR4A1/Mff/…

NR4A1 knockdown confers hepatoprotection against ischaemiareperfusion injury by suppressing TGFβ1 via inhibition of CYR61/NF‐κB in mouse hepatocytes

J Cao, T Xu, C Zhou, S Wang, B Jiang… - Journal of Cellular …, 2021 - Wiley Online Library
… 4, group A, member 1 (NR4A1) can aggravate ischaemia-reperfusion (I/R) injury in the … of
NR4A1 contributes to protection against cardiac microvascular I/R injury through inhibition of …

Dexmedetomidine alleviates pulmonary ischemia-reperfusion injury through modulating the miR-21-5p/Nr4a1 signaling pathway

W Dong, H Yang, M Cheng, X Zhang… - Acta Biochimica …, 2020 - abp.ptbioch.edu.pl
microvascular clip, resulting in pulmonary ischemia for 30 minutes. The microvascular clip
damage is aggravated and even irreversible damage occurs after blood flow restores in the …

The role and regulatory mechanism of HIF-1α in myocardial injury in rats undergoing cardiopulmonary bypass

M Zhang, N Zhou, F Cao, W Liu, H Yuan… - Acta …, 2023 - Taylor & Francis
… CPB-induced myocardial ischaemia-reperfusion injuryNR4A1 aggravates ischaemia-induced
cardiomyocyte apoptosis in patients with metabolic syndrome, and suppression of NR4A1

[HTML][HTML] Kallistatin/Serpina3c inhibits cardiac fibrosis after myocardial infarction by regulating glycolysis via Nr4a1 activation

J Ji, L Qian, Y Zhu, Y Jiang, J Guo, Y Wu, Z Yang… - … et Biophysica Acta (BBA …, 2022 - Elsevier
… At the same time, Nr4a1 plays a role in cardiac microvascular ischemia-reperfusion injury
[37]. … activity decreased, glycolysis increased, and fibrosis was aggravated. To confirm that …

Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials

J Wang, S Toan, H Zhou - Pharmacological Research, 2020 - Elsevier
NR4A1 in mitophagy activation are completely different. Mitophagy is activated by DUSP1
[113] through … and inhibited by NR4A1 [107] through suppression of FUN14 domain containing …

Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein …

Y Zheng, Y Tao, X Zhan, Q Wu - Bioengineered, 2022 - Taylor & Francis
NR4A1 in hepatocyte ischemia-reperfusion injury (IRI). BRL-3A cells were subjected to
hypoxia-… In addition, NR4A1 aggravates cardiac microvascular IRI through suppressing Fundc1-…

[HTML][HTML] Effects of R1-Rg1 on myocardial ischemia-reperfusion injury in mice through mitochondrial autophagy mediated by FUNDC1

Y Sun, D Cai, L Qi, X Song, W Gao, D Wang… - Current Research in …, 2023 - Elsevier
… the enhancement or suppression of mitochondrial autophagy. (… in cardiac microvascular
endothelial cells during the … Our findings indicated an elevation in CK2α and NR4A1 expression …