[HTML][HTML] Dexamethasone-loaded ROS-responsive poly (thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury

Z Zhai, W Ouyang, Y Yao, Y Zhang, H Zhang, F Xu… - Bioactive Materials, 2022 - Elsevier
… decreased lung inflammation, and reduced lung injury and … The intravenously injected
PTKNPs@Dex accumulate in lung, … , a lower level of cytokines and thereby reduced lung injury. …

Role of oxidative stress in nanoparticles toxicity

M Horie, Y Tabei - Free radical research, 2021 - Taylor & Francis
Oxidative stress plays a critical role in nanotoxicity. Various types of nanoparticles are known
to induce oxidative stress by … Cellular uptake of nanoparticles and intracellular metal ion …

Novel drug delivery systems targeting oxidative stress in chronic obstructive pulmonary disease: a review

Y Xu, H Liu, L Song - Journal of nanobiotechnology, 2020 - Springer
… oxide (IV) nanoparticles conjugated with the antioxidative … nanoparticles exhibit intrinsic
oxidant-generating properties. Some silver nanoparticles were found to induce oxidative stress

Nanomedicines targeting respiratory injuries for pulmonary disease management

D Liu, M Long, L Gao, Y Chen, F Li… - Advanced Functional …, 2022 - Wiley Online Library
… major respiratory injuries, acute lung injury, and acute respiratory … lipid nanoparticles, polymeric
nanoparticles, and inorganic … respiratory diseases symptom by reducing oxidative stress

ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment

W Muhammad, J Zhu, Z Zhai, J Xie, J Zhou, X Feng… - Acta biomaterialia, 2022 - Elsevier
oxidative stress [15]. Therefore, blocking the excessive level of ROS to alleviate oxidative
stress is a promising strategy to lessen lung … as scaffolds, hydrogels, and nanoparticles (NPs), …

… silicon dioxide nanoparticles cause lung epithelial cells apoptosis via oxidative stress-activated PI3K/Akt-mediated mitochondria-and endoplasmic reticulum stress …

KI Lee, CC Su, KM Fang, CC Wu, CT Wu, YW Chen - Scientific reports, 2020 - nature.com
… cancer, emphysema, chronic obstructive pulmonary disease, or lungoxidative stress and
activate apoptosis in human lung epithelial derived-A549 cells 16 . Induction of oxidative stress

TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal …

B Han, Z Pei, L Shi, Q Wang, C Li, B Zhang… - International Journal …, 2020 - Taylor & Francis
… In this study, a Nano-TiO 2 exposure rat model through tracheal perfusion was established
to evaluate the effects of Nano-TiO 2 on oxidative stress and DNA damage in the lung, liver, …

Attenuation of cigarette-smoke-induced oxidative stress, senescence, and inflammation by berberine-loaded liquid crystalline nanoparticles: in vitro study in 16HBE …

KR Paudel, N Panth, B Manandhar, SK Singh, G Gupta… - Antioxidants, 2022 - mdpi.com
… for chronic obstructive pulmonary disease. Numerous toxicants present in cigarette smoke
are known to induce oxidative stress and airway inflammation that further exacerbate disease

Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro

KR Paudel, R Wadhwa, M Mehta, DK Chellappan… - Toxicology in vitro, 2020 - Elsevier
… for hydrophobic drugs, the present study was aimed to evaluate the effect of rutin-loaded
liquid crystalline nanoparticles on LPS induced oxidative stress in bronchoepithelial cells. …

Oxidative stress-and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective

X Zhao, A Abulikemu, S Lv, Y Qi, J Duan, J Zhang… - Chemosphere, 2021 - Elsevier
… Five metabolic pathways were significantly perturbed, in particular, oxidative stress- and …
Moreover, SiNPs triggered oxidative stress as confirmed by the dose-dependent ROS …