… The C-terminus of paxillin contains four LIM domains, which are responsible for its FA targeting,
… , FA maturation and the formation of strong traction forces at FAs, although their random …

… Cells perform these functions and are so regulated via the formation of focal adhesions (…
nascent adhesion clusters as sketched in Figure 1a, that we analyze herein. The cell’s adhesion …

… disassembly due to myosin-II mediated traction force generation. … disassembly remain to
be elucidated, our study provided strong evidence in favor of a new model of this process. We …

… Reminiscent of two previous studies, the assembly of nascent adhesions at the leading …
[44]; and nascent adhesions are responsible for the generation of propulsive forces in migrating …

… Nascent focal adhesion (FA) sites start to emerge under the … between adhesion and
intracellular force generation and … a large part of the response may not contribute to propulsion. …

… feedback loop, whereby adhesion-based signaling promotes generation of barbed ends at,
… stationary nascent adhesions either disassemble or grow to form larger focal adhesions ( …

… of actin filaments responsible for generating forces to propel the … directed cell migration begin
as nascent adhesions. These … high forces, the bond between these molecules is not strong …

… Here, using coherence-controlled holographic microscopy (CCHM) for non-invasive live-cell
quantitative phase imaging (QPI), we examined the role of the focal adhesion kinase (FAK) …

… , as following: nascent adhesions or focal complexes (FXs): <… dynamic transmitters of strong
propulsive forces necessary for … to the generation of the tension necessary for focal adhesion …

… This mutant contains the N-terminus region responsible for the … The delay in the generation
of traction forces on substrate upon … FA maturation but rather to a delay in nascent adhesions. …