α-Glucuronosyl and α-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi

S Burugupalli, CF Almeida, DGM Smith, S Shah… - Chemical …, 2020 - pubs.rsc.org
… isolated from the pathogenic fungus Aspergillus fumigatus, … the molecular basis for NKT
cell recognition of this class of … these α-glucosyl and α-glucuronosyl diacylglycerol lipids but …

Type I natural killer T cells as key regulators of the immune response to infectious diseases

NMS Gálvez, K Bohmwald, GA Pacheco… - Clinical Microbiology …, 2021 - Am Soc Microbiol
… for antigen recognition of the T cell receptor (TCR) and the B … The first one is a glucose-linked
diacylglycerol (named Glc-… this pathogen and promote a T H 1-polarized T cell response …

NKT cells contribute to the control of microbial infections

S Vogt, J Mattner - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
… like) T lymphocytes such as natural killer T (NKT) cells play a … Other bacterial NKT cell antigens
are diacylglycerols (DAGs) … -growing, non-pathogenic bacterial species usually detected …

Glycolipid antigen recognition by invariant natural killer T cells and its role in homeostasis and antimicrobial responses

K Hayashizaki, Y Kamii, Y Kinjo - Frontiers in Immunology, 2024 - frontiersin.org
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol.
(2006) … Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive …

Cross talk between natural killer T and dendritic cells and its impact on T cell responses in infections

L Zhao, X Yang - Frontiers in Immunology, 2022 - frontiersin.org
… Unlike conventional T cells, NKT cells recognize glycol- and … Diacylglycerols (DAGs) are
another type of bacterial … 1 NKT cells and inhibition of pathogenic autoreactive CD4 T cells (76, …

Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection

S Genardi, L Visvabharathy, L Cao, E Morgun… - Frontiers in …, 2020 - frontiersin.org
… Despite the traditional thinking that humoral immunity is the main driver of immune defense
against extracellular pathogens, T cells are now recognized as critical players in protection …

Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells

L Valestrand, NL Berntsen, F Zheng… - Clinical & …, 2021 - academic.oup.com
… liver diseases contains antigens that activate natural killer T cells, an important subgroup of
liver lymphocytes. Activation of … iNKT cells recognize microbial antigens from both pathogenic

T cell immunity to bacterial pathogens: mechanisms of immune control and bacterial evasion

FR Shepherd, JE McLaren - International journal of molecular sciences, 2020 - mdpi.com
… of how T cells recognize bacterial antigens and how many bacterial … of how T cell immunity
responds to bacterial pathogens and … T (MAIT) cells and invariant natural killer T (iNKT) cells, …

Potential role of diacylglycerol kinases in immune-mediated diseases

G Baldanzi, B Ragnoli, M Malerba - Clinical Science, 2020 - portlandpress.com
natural killer T cell (iNKT) indicates that DGKα and DGKζ synergistically regulate T and
iNKT-cell … , reducing the accumulation of pathogenic, activated CD8 + T cells and thus mitigating …

From the banal to the bizarre: unravelling immune recognition and response to microbial lipids

L Burchill, SJ Williams - Chemical Communications, 2022 - pubs.rsc.org
T cells can recognize lipid antigens when presented at the … CD1d proteins present
glycolipids to natural killer T (NKT) cells… The diacylglycerol was assembled using the method …