Natural killer cell therapy targeting cancer stem cells: old wine in a new bottle

F Guo, Y Zhang, L Bai, J Cui - Cancer Letters, 2023 - Elsevier
… conversion between differentiated tumor cells and CSCs under … cancer, estrogen receptor-α
positive breast cancer stem-like … increased ability to target solid tumor stem-like cells both in …

[HTML][HTML] Natural killer cells: diverse functions in tumor immunity and defects in pre-neoplastic and neoplastic stages of tumorigenesis

A Jewett, J Kos, K Kaur, T Safaei, C Sutanto… - Molecular Therapy …, 2020 - cell.com
… /undifferentiated tumors via lysis, and secreted or membrane-… of NK cells in selection and
differentiation of stem-like tumorstargeting cancer stem-like/undifferentiated tumors, NK cells

[HTML][HTML] … MICA/B is mediated against differentiated oral and pancreatic and not stem-like/poorly differentiated tumors by the NK cells; loss in cancer patients due to …

K Kaur, T Safaie, MW Ko, Y Wang, A Jewett - Cancers, 2021 - mdpi.com
Natural Killer cells are known to eliminate tumors directly or via … of tumor killing. In this
report we provide evidence that NK cells mediate killing of both stem-like/poorly differentiated

Multifaceted nature of natural killer cells: Potential mode of interaction and shaping of stem cells

E Senjor, MW Ko, K Kaur, PC Chen, B Breznik… - NK Cells in Cancer …, 2023 - Elsevier
… , as they were only able to kill certain tumor cells, but not those highly susceptible to T cell
they preferentially targeted cancer stem-like cells (CSCs)/poorly-differentiated tumor cells that …

[HTML][HTML] Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas

K Kaur, J Sanghu, S Memarzadeh, A Jewett - Vaccines, 2024 - mdpi.com
cancers (HGSOCs) likely consist of poorly differentiated stem-like cells (PDSLCs) and
differentiated tumor cells. … will refer to these cells as poorly differentiated stem-like cells (PD-SLCs) …

[HTML][HTML] Natural killer cells efficiently target multiple myeloma clonogenic tumor cells

A Leivas, RM Risueño, A Guzmán… - Cancer Immunology …, 2021 - Springer
… of immune cells, such as T cells and natural killer (NK) cells, is … cell capacity to kill transformed
or infected cells and tumor … of stem cell differentiation and stem cell maintenance were …

Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro

K Kaur, A Jewett - Critical Reviews™ in Immunology, 2024 - dl.begellhouse.com
… oral tumors: oral squamous carcinoma stem-like cells (OSCSCs) and oral squamous …
Natural killer cells target and differentiate cancer stemlike cells/undifferentiated tumors: Strategies …

[HTML][HTML] EpCAM-high liver cancer stem cells resist natural killer cell–mediated cytotoxicity by upregulating CEACAM1

DJ Park, PS Sung, JH Kim, GW Lee… - … of cancer, 2020 - ncbi.nlm.nih.gov
… were shown to be major immune effectors with the ability to target and shape several
poorly differentiated tumors, such as oral, glioblastoma, pancreatic, and melanoma …

Advances in natural killer cell therapies for breast cancer

SZF Kiaei, A Nouralishahi… - … and Cell Biology, 2023 - Wiley Online Library
Natural killer (NK) cells are an essential component of innate immunity and are critical in
destroying tumor cells without … HLA alleles determine differences in human natural killer cell

Novel strategies to expand supercharged NK cells with augmented capacity to withstand inactivation by tumors

A Jewett, J Kos, TL Turnsek, PC Chen, B Breznik… - … and Challenges of NK …, 2021 - Elsevier
Natural killer (NK) cells are the main immune effectors with … /undifferentiated or poorly
differentiated tumors via lysis, and … role in targeting cancer stem-like/undifferentiated tumors, and a …