The role of Gardnerella in bacterial vaginosis and facilitating colonization by Neisseria gonorrhoeae

SR Morrill - 2023 - search.proquest.com
… developed different strategies for infecting different sites in the human … as its primary
mechanism for infecting the lower female … cytolysins and cervical epithelial cells may facilitate N. …

[HTML][HTML] Neisseria gonorrhoeae subverts formin-dependent actin polymerization to colonize human macrophages

SS Ivanov, R Castore, MD Juarez Rodriguez… - PLoS …, 2021 - journals.plos.org
infections [5] remain underexplored. Important work using human cervical tissue explants
demonstrated that N.g … protein invade human cervical and endometrial epithelial cell lines. …

A Little Complement Goes a Long Way: Neisseria gonorrhoeae and Membrane-Bound Complement Inhibitors

PM Zdinak - 2020 - rave.ohiolink.edu
… complement inhibitors expressed on infected epithelial cells. … of cells that displayed
heterogenous levels of CD46 in the BC1 … which are derived from cervical epithelial cells, Hec1b …

[HTML][HTML] Epidemiology, Treatments, and Vaccine Development for Antimicrobial-Resistant Neisseria gonorrhoeae: Current Strategies and Future Directions

EY Lin, PC Adamson, JD Klausner - Drugs, 2021 - Springer
gonorrhoeae infections, reviving the use of ciprofloxacin in strains … However, the wide genetic
heterogeneity and multiple mechanisms … When used for cervical cell infection by MDR N. …

The Gonococcal Genetic Island defines distinct sub-populations of Neisseria gonorrhoeae

MA Youngblom, AC Shockey… - Microbial …, 2023 - microbiologyresearch.org
… model of rate heterogeneity. Phylogenetic trees were plotted … show defects in biofilm formation
on human cervical cells [62]. … and urethral epithelia [64], and biofilms have been observed …

Characterization of Neisseria gonorrhoeae colonization of macrophages under distinct polarization states and nutrients environment

…, M Marquette, R Youngblood, N Dhungel… - bioRxiv, 2024 - biorxiv.org
… Ng mainly 69 colonizes and infects the urogenital tract (3). In … acute gonorrhea besides
neutrophils and exfoliated epithelial … (F) Gonococcal invasion of a heterogenous pool of M0 or M1 …

[HTML][HTML] Organoids of the female reproductive tract

C Chumduri, MY Turco - Journal of molecular medicine, 2021 - Springer
… The mucosal epithelial lining of different regions of the FRT—ovaries, fallopian tubes, … HeLA
(cervical carcinoma), are karyotypically abnormal and do not represent the heterogeneity of …

Role of the gonococcal neisserial heparin binding antigen in microcolony formation, and serum resistance and adherence to epithelial cells

EA Semchenko, TD Mubaiwa, CJ Day… - The Journal of …, 2020 - academic.oup.com
human serum and reduced adherence to human cervical and urethral … Neisseria gonorrhoeae
is an obligate human pathogen that … GAG structures are highly heterogeneous, comprising …

Models for sexually transmitted infections

K Knapp, G Stary - Drug Discovery Today: Disease Models, 2020 - Elsevier
… trachomatis and Neisseria gonorrhea, monolayers of cervical, … organoids from cervical and
endometrial epithelium were … heterogenous endometrial diseases and allow to think about …

[HTML][HTML] Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

S Gao, L Gao, D Yuan, X Lin, S van der Veen - Nature Communications, 2024 - nature.com
… pathogen Neisseria gonorrhoeae is able to invade epithelial … in disseminated gonococcal
infections 4,5,6 . Intracellular … in epithelial cells though a dual PorB-dependent mechanism. …