… with the exhaustion of nephron progenitor cells. Consequently, no nephrons are formed after
… the complement of nephrons generated during gestation. In humans, a tenfold variation in …

… and differentiation of nephron progenitor cells. Here, we … leads to a rapid decline of nephron
progenitors. By contrast, tissue … R-spondins, only mildly affects progenitor numbers, but does …

… of metanephros with bladders B Nephron progenitor cells/nephron induction from induced
pluripotent stem cells B Dissociation of nephron progenitor cell spheres B Flow cytometry …

Background We reasoned that unraveling the dynamic changes in accessibility of genomic
regulatory elements and gene expression at single-cell resolution will inform the basic …

… Understanding how the precise gene expression states that define nephron progenitor cell
… nephron. Combination of Eya1-Six1/2 has been explored in inducing nephron progenitor–…

… A number of studies have delineated signalling nodes that regulate positional identities
and cell fates of nephron progenitor and precursor cells, whereas cross-species comparisons …

… nephron progenitor pool determines nephron endowment. There appears to be no mechanisms
that sense nephron … in the pool of progenitors to restore the number of nephrons to the …

… In this study, we conducted experiments using selectively induced nephron progenitor
cells as human side cells because we hypothesized that mixing nephron progenitor cells with …

… —are necessary for nephron progenitor differentiation and nephron endowment, we generated
mice with deletion of Tet1, Tet2, or Tet3 in Six2-positive nephron progenitors cells (NPCs)…

… nephrons. Therefore, understanding the signaling molecules that regulate nephron progenitor
… Sprouty1 regulates nephron progenitor maintenance by inhibiting Fibroblast growth factor …