… ) in E14.5 mouse NPCs and is thought to represent a transitional state between nephron
progenitor and early nascent nephrons. Lastly, the NPC7 cluster represents nephron progenitor-…

… regulation of nephron progenitors contribute to only a fraction of reduced nephron mass …
The importance of MAPK/ERK activation in nephron progenitor maintenance has been …

… This delicate balance between nephron progenitor renewal and differentiation is essential
for kidney development, because failure to achieve adequate numbers of nephrons is a risk …

… iPSC)-derived nephron progenitors and in our understanding of how nephrons form in a kidney
… clues as to how we might use iPSC-derived cells to regenerate a human nephron in vivo. …

… ,” aiming to regenerate human nephrons using porcine fetal kidneys as a scaffold. Crucial
to this approach is the replacement of porcine nephron progenitor cells (NPCs) with human …

… nephrons forming in the third trimester. Infants born before 30 weeks undergo nephrogenesis
for no more than 40 days postnatally, resulting in low nephron … Six1 (nephron progenitors, …

… chimeric nephrons exhibit similar maturation to the host nephrons, … human nephron progenitor
cells differentiate into nephrons … approach for in vivo nephron generation, with potential …

… of nephron progenitor population from PSCs. Until now, differentiation of PSCs into ureteric
bud (UB) progenitor … We and several other groups reported induction of nephron progenitors, …

… are expressed in nephron progenitors of human … nephron progenitors throughout development.
This non-overlapping expression between Six1 and Six2 in mouse nephron progenitors …

… Here we find that the avalanche-like commitment of nephron progenitors coincides with …
pauses 29 in which nephron progenitors renew. This may act to match nephron formation rate to …