The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice
H Liu, S Hilliard, E Kelly, CH Chen, Z Saifudeen… - Journal of Biological …, 2020 - ASBMB
… ) in E14.5 mouse NPCs and is thought to represent a transitional state between nephron
progenitor and early nascent nephrons. Lastly, the NPC7 cluster represents nephron progenitor-…
progenitor and early nascent nephrons. Lastly, the NPC7 cluster represents nephron progenitor-…
Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism
HN Kwon, K Kurtzeborn, V Iaroshenko, X Jin… - …, 2022 - journals.biologists.com
… regulation of nephron progenitors contribute to only a fraction of reduced nephron mass …
The importance of MAPK/ERK activation in nephron progenitor maintenance has been …
The importance of MAPK/ERK activation in nephron progenitor maintenance has been …
Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus
… This delicate balance between nephron progenitor renewal and differentiation is essential
for kidney development, because failure to achieve adequate numbers of nephrons is a risk …
for kidney development, because failure to achieve adequate numbers of nephrons is a risk …
Recreating, expanding and using nephron progenitor populations
MH Little, KT Lawlor - Nature Reviews Nephrology, 2020 - nature.com
… iPSC)-derived nephron progenitors and in our understanding of how nephrons form in a kidney
… clues as to how we might use iPSC-derived cells to regenerate a human nephron in vivo. …
… clues as to how we might use iPSC-derived cells to regenerate a human nephron in vivo. …
Modeling Kidney Development, Disease, and Plasticity with Clonal Expandable Nephron Progenitor Cells and Nephron Organoids: SA-PO342
… ,” aiming to regenerate human nephrons using porcine fetal kidneys as a scaffold. Crucial
to this approach is the replacement of porcine nephron progenitor cells (NPCs) with human …
to this approach is the replacement of porcine nephron progenitor cells (NPCs) with human …
Evidence for Post-Branching Nephrogenesis and Novel Ureteric Bud/Nephron Progenitor Interaction in the Postnatal Rabbit: FR-PO392
MP Schuh, S Yarlagadda, L Alkhudairy… - Journal of the American …, 2022 - journals.lww.com
… nephrons forming in the third trimester. Infants born before 30 weeks undergo nephrogenesis
for no more than 40 days postnatally, resulting in low nephron … Six1 (nephron progenitors, …
for no more than 40 days postnatally, resulting in low nephron … Six1 (nephron progenitors, …
Long-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity
K Matsui, S Yamanaka, S Chen, N Matsumoto… - Communications …, 2023 - nature.com
… chimeric nephrons exhibit similar maturation to the host nephrons, … human nephron progenitor
cells differentiate into nephrons … approach for in vivo nephron generation, with potential …
cells differentiate into nephrons … approach for in vivo nephron generation, with potential …
Mouse embryonic stem cell-derived ureteric bud progenitors induce nephrogenesis
Z Tan, A Rak-Raszewska, I Skovorodkin, SJ Vainio - Cells, 2020 - mdpi.com
… of nephron progenitor population from PSCs. Until now, differentiation of PSCs into ureteric
bud (UB) progenitor … We and several other groups reported induction of nephron progenitors, …
bud (UB) progenitor … We and several other groups reported induction of nephron progenitors, …
Six1 and Six2 of the sine oculis homeobox subfamily are not functionally interchangeable in mouse nephron formation
J Xu, J Li, A Ramakrishnan, H Yan, L Shen… - Frontiers in Cell and …, 2022 - frontiersin.org
… are expressed in nephron progenitors of human … nephron progenitors throughout development.
This non-overlapping expression between Six1 and Six2 in mouse nephron progenitors …
This non-overlapping expression between Six1 and Six2 in mouse nephron progenitors …
Nephron progenitors rhythmically alternate between renewal and differentiation in synchrony with kidney branching morphogenesis.
SN Davis, SH Grindel, JM Viola, GY Liu… - Biorxiv: the Preprint …, 2023 - europepmc.org
… Here we find that the avalanche-like commitment of nephron progenitors coincides with …
pauses 29 in which nephron progenitors renew. This may act to match nephron formation rate to …
pauses 29 in which nephron progenitors renew. This may act to match nephron formation rate to …