… A fraction of CM cells differentiates into nephron progenitor (NP) cells, which migrate towards
… The PTA transforms into the renal vesicle, from which the final structures of the nephron, ie …

… The ureteric tip and stalk arise as a side branch of the nephric duct, which is itself initiated
from a more anterior intermediate mesoderm than the metanephric nephron progenitors. As …

… +/− nephron progenitor cells from mice with elevated nephron … This suggests that the tipping
point for nephron progenitor exit … in nephron progenitors delays cessation and increases …

… cell (RSPC) niche in the nephrogenic zone and regulation of nephron progenitor … nephron
progenitors. WNT signaling is inactive in the absence of WNT ligands (left). In early progenitor …

… To disrupt centrosome biogenesis and cause centrosome loss in a spatiotemporally
controlled manner in nephron progenitor cells, we used a recently developed mouse model …

… Nephron development proceeds with reciprocal interactions among three layers: nephron
progenitors (NPs), ureteric buds and stromal progenitors (SPs). We found that Foxc1 and …

… tips promote nephron formation from dedicated progenitor cells. While nephron progenitor
cells are relatively well characterized, the origin of ureteric bud progenitors has received little …

… progenitor population, which we sought to do by identifying miRNA expressed in nephron
progenitors… Finally, we measured heterogeneous gene expression of the progenitor population …

… Nephron number additionally depends on the molecular regulation and maintenance of
the nephron progenitors. As the kidney is a non-regenerating organ, nephron endowment is …

… Impaired renewal or differentiation of nephron progenitor cells (NPC) can impede
nephrogenesis and result in nephron deficit and hypoplasia of the kidney, one of the hallmarks of …