Deletion of NuRD component Mta2 in nephron progenitor cells causes developmentally programmed FSGS

J Basta, L Robbins, L Stout, M Brennan, J Shapiro… - bioRxiv, 2023 - biorxiv.org
… in nephron progenitor cells results in renal hypoplasia To investigate the role of Mta2 in nephron
progenitor … In Mta2flx/flx control kidneys, Mta2 was detected in nephron progenitor cells, …

Bioenergetic evolution explains prevalence of low nephron number at birth: risk factor for CKD

RL Chevalier - Kidney360, 2020 - journals.lww.com
… Although low nephron number is a recognized risk factor for CKD… nephron number. Regulated
through placental transfer, environmental oxygen and nutrients signal nephron progenitor

[HTML][HTML] Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches

JM Viola, J Liu, A Huang, SH Grindel, LS Prahl… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… We find that the ROCK inhibitor Y-27632 increases mixing between nephron progenitor
and stromal compartments in native mouse embryonic kidney niches, and also increases …

Nephron progenitor maintenance is controlled through FGFs and Sprouty1 Interaction

SH Huh, L Ha, HS Jang - bioRxiv, 2020 - biorxiv.org
nephron progenitor maintenance by inhibiting FGF signal. Deletion of Sprouty1 rescues renal
agenesis and nephron progenitor … in failure of nephron progenitor maintenance. This study …

[PDF][PDF] In vivo regeneration of interspecies chimeric kidneys using a nephron progenitor cell replacement system

藤本俊成 - Scientific Reports, 2021 - ir.jikei.ac.jp
… exogeneous nephron progenitor cells (… neo-nephrons on a culture dish. To apply this method
to humans in the future, we examined the possibility of the in vivo regeneration of nephrons

[HTML][HTML] Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney

JO Lamontagne, H Zhang, AM Zeid… - Nature …, 2022 - nature.com
nephron segments except for medullary collecting ducts. Inactivation of AP-2α in nephron
progenitor … Heterozygosity for AP-2β in nephron progenitor cells leads to progressive distal …

Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer–Promoter Interactions in the Transgene

AJ Perl, H Liu, M Hass, N Adhikari… - Journal of the …, 2024 - journals.lww.com
… a mesenchymal nephron progenitor cell population. Low … Reduced nephron numbers in the
popular Six2TGC transgenic … were generated from nephron progenitor cells isolated from the …

A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron

ME Corkins, MA Achieng, BD DeLay… - Kidney international, 2023 - Elsevier
… Genes coding for transporters are segmentally expressed, enabling the nephron to … large
nephron, has served as a valuable model to identify genes involved in nephron formation and …

Histone deacetylases 1 and 2 target gene regulatory networks of nephron progenitors to control nephrogenesis

H Liu, NYN Ngo, KF Herzberger, M Gummaraju… - Biochemical …, 2022 - Elsevier
… interactions with the transcriptional programs of nephron progenitors and renal vesicles [11]…
of Hdac1/2 in mouse nephron progenitors by chromatin immunoprecipitation followed by …

[HTML][HTML] Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance

J Huang, Y Kong, C Xie, L Zhou - Stem Cell Research & Therapy, 2021 - Springer
… In S3 segment of nephron, there is a group of Pax-2 + stem/progenitor cells, which have the
perfect repair capabilities although they have an immature tubular epithelial-like phenotype. …