The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders

KM Lee, ZH Hawi, HC Parkington, CL Parish… - Molecular …, 2020 - nature.com
bipolar disorders and schizophrenia, patient-derived models … future modelling efforts of
neurodevelopmental disorders. Future … iPSC-based disease modelling studies in these disorders. …

Mental health dished up—the use of iPSC models in neuropsychiatric research

RV McNeill, GC Ziegler, F Radtke, M Nieberler… - Journal of Neural …, 2020 - Springer
… bona fide iPSC cell line of a Chinese bipolar patient carrying … one bone fide iPSC cell lines
from a bipolar patient who is a … GAT) and from another bipolar patient who is a carrier of the …

Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell models

A Perrottelli, FF Marzocchi, E Caporusso… - Journal of Psychiatry and …, 2024 - jpn.ca
iPSC-based research on schizophrenia and bipolar disorder, showing disturbances in
neurodevelopmental … of studies developing iPSC models of both diseases simultaneously, and …

Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder

K Phalnikar, M Srividya, SV Mythri… - Oxford Open …, 2024 - academic.oup.com
… In summary, in this study we model early neurodevelopmental deficits in bipolar patients …
any potential neurodevelopmental origins of the disorder. We have utilised iPSC lines from BD …

[PDF][PDF] Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder

SS Mishra, SK Dhanya, P Paul, B Holla, S Ganesh… - 2024 - researchgate.net
… In summary, in this study we model early neurodevelopmental deficits in bipolar patients …
any potential neurodevelopmental origins of the disorder. We have utilised iPSC lines from BD …

Using iPSC models to understand the role of estrogen in neuron–glia interactions in schizophrenia and bipolar disorder

D Reis de Assis, A Szabo, J Requena Osete, F Puppo… - Cells, 2021 - mdpi.com
… induced pluripotent stem cell (iPSC) models to revisit studies of … in the iPSC field, emphasizing
the potential of using patient-… associations in SCZ and neurodevelopmental disorders [62]. …

Astrocyte-derived exosomes in an iPSC model of bipolar disorder

D Attili, DJ Schill, CJ DeLong, KC Lim, G Jiang… - Neurodevelopmental …, 2020 - Springer
… may be involved in neurodevelopmental, neuropathological, … from four bipolar disorder (BP)
and four control (C) iPSC lines… exosomes derived from bipolar patient and control astrocytes …

Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder

G Yang, HMA Ullah, E Parker, B Gorsi, M Libowitz… - Molecular …, 2023 - nature.com
… in patient iPSC-derived neurons, we treated both iPSC-… iPSC-based models generated from
BD patients have uncovered cellular deficits related to various aspects of neurodevelopment

Emerging developments in human induced pluripotent stem cell-derived microglia: implications for modelling psychiatric disorders with a neurodevelopmental origin

B Hanger, A Couch, L Rajendran, DP Srivastava… - Frontiers in …, 2020 - frontiersin.org
… of potential relevance to using human iPSC-derived microglia for studying neuropsychiatric
… mortem brain tissue of individuals with bipolar disorder suggests these cells are not activated …

Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids

JR Osete, IA Akkouh, O Ievglevskyi… - Molecular …, 2023 - nature.com
modeling BD-related disease mechanisms. We studied the effects of 1 mM Li treatment for 1
month in iPSC-… of patient iPSC-derived 3D brain models for precision medicine in psychiatry. …