Neuroendocrine-immune crosstalk shapes sex-specific brain development

SE Arambula, MM McCarthy - Endocrinology, 2020 - academic.oup.com
sex differences and review the concept of sexual differentiation of the brain, a process occurring
early in development … developmental sex differences in the neuroimmune system, which …

Role of epigenetics in shaping sex differences in brain development and behavior

LR Cortes, NG Forger - Perinatal and Developmental Epigenetics, 2023 - Elsevier
sex differences in the brain and downstream behaviors. In this chapter, we review the evidence
for sex differences found across different … , and microRNAs) in human and rodent brains. …

A new view of sexual differentiation of mammalian brain

MM McCarthy - Journal of Comparative Physiology A, 2020 - Springer
Establishment of enduring sex differences in brain and behavior occurs during pre- or perinatal
development, … impact on developing brain. An increasing awareness of the importance of …

Origins of sex differentiation of brain and behavior

MM McCarthy - Developmental Neuroendocrinology, 2020 - Springer
… are often established early in development when the brain is … As a result, there was little
thought given to sex differences … The term neuroepigenetics was coined in recognition of the …

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment

M Schwabenland, O Mossad, A Sievert… - Nature …, 2023 - nature.com
… often show a sex bias 16 , the observed sex differences in … brain development already during
embryonic development, … alterations in neuroimmune function is whether the brain has the …

Sex differences in the development of the rodent corticolimbic system

H Premachandran, M Zhao… - Frontiers in …, 2020 - frontiersin.org
… current principles on sexual differentiation of the rodent brain. We then … differ in male and
female rodents. Importantly, we also explore how sex differences that exist during development

Epigenetic Regulation of Sexually Divergent Neuroinflammation with Brain Aging and Alzheimer's Disease

SR Ocañas - 2022 - search.proquest.com
… During fetal development, in addition to guiding the development of sex-specific tissue (…
roles in establishing sex differences in the developing brain [117]. In males, testes development

The close link between the fetal programming imprinting and neurodegeneration in adulthood: The key role of “hemogenic endothelium” programming

A Allegra, RM Giarratana, L Scola… - … of ageing and development, 2021 - Elsevier
brain development are also dependent on sex differences. … during development, depending
on regional differences in … to the major processes of brain development, demonstrated to …

Sex differences in the brain transcriptome related to alcohol effects and alcohol use disorder

R Hitzemann, SE Bergeson, AE Berman, JA Bubier… - Biological …, 2022 - Elsevier
… of neuroimmune processes. Microglia are the resident neuroimmune cells in the brain and
… neurons (70,71), and development and maintenance of perineuronal nets. In the adult …

DNA methylation and demethylation underlie the sex difference in estrogen receptor alpha in the arcuate nucleus

LR Cortes, CD Cisternas, INKV Cabahug… - …, 2022 - karger.com
… life underlies the emergence of many sex differences in the mammalian brain [1, 2]. For …
To test the role of demethylation in the development of the sex difference in ERα expression …