… DFP is an iron chelator widely used for the treatment of thalassemia and other systemic iron
overload diseases, showing high affinity and selectivity for iron.29, 30 The characteristics of …

… Novel iron chelating agents such as natural remedies are useful to decrease the side effects
of iron in the … A study investigated the neuroprotective and chelating capacities of green tea …

… In iron-deficient cells, IRPs selectively bind IRE at 5 UTR of the mRNA coding for ferritin
and … by which it exerts neuroprotective activity is through decreasing redox-active iron [170]. …

… of the irreversible selective MAO-B inhibitor and neuroprotective/neurorestorative drug,
rasagiline, … iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in …

… Ferroptosis is a novel type of cell death characterized by iron-… Building on these findings,
we can selectively induce … Another study showed that Fer-1 had a significant neuroprotective …

… B) with different substrate selectivity and tissue expression patterns led to novel therapeutic
… is a multitarget iron chelator that exhibits brain-selective MAO inhibition and neuroprotection …

… a longer duration and exhibit neuroprotective effects against various … novel multifunctional
agents with D 3 -preferring agonist activity along with antioxidant activity, such as the selective …

… Collectively, the current work offers a few recommendations according to published reports
and … Maintenance in metal homeostasis may illuminate potential novel therapeutic targets for …

… Based on the challenges and the roadblocks, we believe that the rational design of multi-target
ligands able to modulate the complex network of events behind the disease can provide …

… and iron toxicity, have potentially opened up possibilities of a wide variety of novel treatments,
… Particularly, minocycline may have some neuroprotective activity in various experimental …