Systematic review of erythropoietin (EPO) for neuroprotection in human studies

S Hemani, O Lane, S Agarwal, SP Yu… - Neurochemical …, 2021 - Springer
… Schematic of the neuroprotective mechanisms of EPO. Endogenous and exogenous EPO
for existing studies that evaluated the neuroprotective benefits of EPO in normonemic adults. A …

Erythropoietin and derivatives: Potential beneficial effects on the brain

DC Vittori, ME Chamorro, YV Hernández… - Journal of …, 2021 - Wiley Online Library
… This review will focus on the discussion of experimental evidence reported … mechanisms
for novel derivatives which may clarify and, eventually, improve the neuroprotective action of Epo

[HTML][HTML] Neuroprotective mechanisms of erythropoietin in a rat stroke model

M Juenemann, T Braun, N Schleicher… - Translational …, 2020 - degruyter.com
Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo
experimental models for hypoxia/ischemia. Brain Res Rev. 2008;59:22–33.10.1016/j.brainresrev.…

[HTML][HTML] Potential anti-inflammatory effect of erythropoietin in non-clinical studies in vivo: A systematic review

I Silva, C Alípio, R Pinto, V Mateus - Biomedicine & Pharmacotherapy, 2021 - Elsevier
… The EPO mechanism of action is triggered when EPO receptor (EPOR) is activated by EPO
… anti-inflammatory effect, neuroprotection, and tissue regeneration [2], [3], [6], [9]. Despite this, …

Neuroprotection induced by erythropoietin

RE Maltaneri, ME Chamorro, AB Nesse… - … in Neuroprotection and …, 2024 - Elsevier
… on the neuroprotective mechanisms and actions of Epo. … We demonstrated neuroprotective
effects of Epo on cultures of the … In our experimental model of apoptosis induced by TNF-α in …

Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer's disease

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Metabolic brain …, 2022 - Springer
… both in vitro and in vivo, have been conducted to identify the various mechanisms by which
erythropoietin exerts its … In vitro administration of EPO in experimental models of AD produces …

[HTML][HTML] Development of a neuroprotective erythropoietin modified with a novel carrier for the blood–brain barrier

PC Chiu, HC Liou, TY Ling, LJ Shen - Neurotherapeutics, 2020 - Springer
… (29.9 ± 7.0% vs 48.9 ± 7.9%) 24 h after occlusion in 3VO rat experiments. Moreover, the …
However, the mechanism that affects the distribution of EPO-HBHAc needs to be further studied. …

[HTML][HTML] Current evidence on the protective effects of recombinant human erythropoietin and its molecular variants against pathological hallmarks of Alzheimer's …

JJ Jarero-Basulto, MC Rivera-Cervantes… - Pharmaceuticals, 2020 - mdpi.com
… studied effects of the EPO molecule is neuroprotection through anti-apoptotic mechanisms
[40,… Currently, there is more experimental evidence in vitro on the inhibition of the Aβ effect by …

[HTML][HTML] Neuroprotective properties of peptides

O Erbas, İ Altuntaş, P Nesil, H Sasani, M Odabaşı - 2023 - intechopen.com
… details about the roles of erythropoietin (EPO), glucagon-like … molecular mechanisms they
trigger to elicit the neuroprotective … Numerous animal experiments published in the literature …

[HTML][HTML] Whether erythropoietin can be a neuroprotective agent against premature brain injury: Cellular mechanisms and clinical efficacy

X Ma, Y Shi - Current Neuropharmacology, 2022 - ncbi.nlm.nih.gov
… Current experimental evidence suggests that neuroprotection requires high doses of systemic
rhEpo administration, which may increase the risk of other side effects. Hence, enhancing …