… induces a neurotoxic reactive astrocyte phenotype that is paired with loss of RGCs. We also
show that blocking this reactive … secreted from microglia that induce neurotoxic reactive astro…

… Here we show that neurotoxic reactive astrocytes drive the death of neurons and mature
oligodendrocytes through the delivery of FFAs and VLCPCs, probably via lipoparticle secretion. …

… gene and having microglia C3R on its membrane (Lian et al., 2015). In agreement, we
found that LPS-exposed astrocytes induced C3 gene expression and that microglial cells from …

… the identity and function of reactive and activated glia In this review, we discussed the
morphology and immunophenotype of activated microglia and reactive astrocytes, as well as what …

… We hypothesized that similar to microglia, the brain immune cells, reactive astrocytes can
release a broader set of diverse molecules that are potentially neurotoxic. A literature search …

… Aβ-induced activation of GLP-1R + microglia by subcutaneous … acting GLP-1R agonist,
prevents reactive astrocytes conversion, … upon reactive astrocytes through Aβ-activated microglia. …

… In summary, extracellular dysfunctional fragmented mitochondria released by activated
microglia induces polarization of local astrocytes, releasing their own mitochondrial fragments, …

… Moreover, it has been reported that the activated microglia and reactive astrocytes influence
each other. Due to the complexity of microglia and astrocyte phenotypes and the various …

… diverse group of less-established microglia neurotoxins, which were selected by applying
the two criteria that these molecules 1) can be released by microglia, and 2) have the potential …

… by microglia were drivers of the gene expression profiles of neurotoxic reactive astrocytes
8,36 , … free fatty acids as astrocyte-derived toxic molecules 95 . To date, only two inflammation-…