… Here, we reported the synthesis of the Tacrine-cinnamic acid derivatives hybrids with
different substituent groups and linkers (Scheme 29). Anthranilic acid 222 was condensed with …

… in patients with mild-to-moderate dementia of Alzheimer disease [21,22]. THA undergoes
first pass … In addition, in 2021 Mak et al. summarized multifunctional dimers, including THA–…

… -based hybrid molecules for the treatment of Alzheimer's … 35, 4-chlorobenzyl 4-oxo-4H-chromene-3-carboxylate,
was a … 38 was twofold more potent than tacrine, 35-fold more potent than …

… synthesis of tacrine–flavonoid and flavonoid–basic side-chain hybrids as multifunctional ChE
… (5) are commercially available, whereas the 4-oxo-4H-chromene-3-carboxylic acids (3a–3g…

… A family of tacrine and 4-oxo-4H-chromene hybrids was … -6-chloro-tacrine hybrids with
potent inhibitory activities against … The presented hybrid protects transgenic mice from cognitive …

… with a cholinergic deficit, prominently Alzheimer’s disease (AD… We pioneered the use of
molecular hybridization to design … ring of tacrine led to a class of huperzine A−tacrine hybrids (…

… Molecular modeling studies were also conducted to evaluate the novel hybrid compounds’
… of donepezil-chromone hybrids 160–167 and 168–175; they were prepared by treating 2-…

… ring, holds a prominent position in medicinal chemistry as a versatile building block for
synthesizing various pharmacologically active agents. Its prevalence is not limited to natural …

… hybrid, and tacrine 4 oxo 4 H chromene hybrid. Structure and activity details of tacrine-based
hybrids … It is a multifunctional ligand with broad-spectrum anti-Alzheimer’s properties like …

… Among the 12 hybrids synthesized and evaluated for their … . developed a series of hybrid
derivatives combining tacrine and L-… into tryptamine to confer multifunctional properties to the 12 …