Synthesis of new pyrazolone and pyrazole-based adamantyl chalcones and antimicrobial activity

R Al-Saheb, S Makharza, F Al-Battah… - Bioscience …, 2020 - portlandpress.com
… were prepared by condensation of 1-adamantyl methyl ketone with pyridine-2-… adamantyl
chalcone compounds were prepared, wherein the chalcone moiety is an intermediate to new

Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities

M Ao, X Hu, Y Qian, B Li, J Zhang, Y Cao, Y Zhang… - Bioorganic …, 2021 - Elsevier
… , a new series of chalcone adamantly arotinoids (chalcone AdArs) derived from RAR antagonist
MX781, are synthesized, … , a new class of chalcone AdArs was synthesized as anticancer

Synthesis and bioactivity of thiosemicarbazones containing adamantane skeletons

VH Pham, TPD Phan, DC Phan, BD Vu - Molecules, 2020 - mdpi.com
… In this study, 4-(1-adamantyl)-3-thiosemicarbazide (1) was synthesized by the reaction of
adamantan-1-yl isothiocyanate (Sigma Aldrich, MO, USA) with 80% hydrazine hydrate solution (…

[PDF][PDF] Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis

MH Nematollahi, M Mehrabani, Y Hozhabri… - Heliyon, 2023 - cell.com
… on the antibacterial and antiviral effects of chalcones and their … of greener techniques for
synthesizing these compounds are … , the antimicrobial activity of five pyrazole-based adamantyl

Synthesis and in vitro antibacterial, antifungal, anti-proliferative activities of novel adamantane-containing thiazole compounds

ET Warda, MB El-Ashmawy, ESE Habib… - Scientific reports, 2022 - nature.com
… retinoid CD437 was also reported as a promising anticanceradamantane-based anticancer
drug for the treatment of advanced solid tumors 12 . Opaganib induces its anticancer activity

Recent progresses in chalcone derivatives as potential anticancer agents

J Yang, J Lv, S Cheng, T Jing, T Meng… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
… The antitumor activity of the coumarin-chalcone hybrid (11) was stronger than xanthohumol,
and it could induce apoptosis of cancer cells by stimulating intracellular reactive oxygen …

Chalcone derivatives: Role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
chalcones as potential anticancer agents has inspired many efforts directed to developing
novel synthetic chalcones with anticancer properties. … of the chalcone structure have promoted …

Isatin-Schiff's base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation

EA Fayed, RRE Eldin, ABM Mehany… - Journal of Molecular …, 2021 - Elsevier
… base and chalcone were synthesized and screened for their anticancer activities against …
All the tested compounds exhibited moderate to high antitumor activity with IC 50 ranging from …

[PDF][PDF] Chalcone Derivatives: Role in Anticancer Therapy. Biomolecules 2021, 11, 894

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - 2021 - researchgate.net
Synthetic Chalcone Derivatives … occurring chalcones as potential anticancer agents has
inspired many efforts directed to developing novel synthetic chalcones with anticancer properties

Novel Adamantane-Linked Isothiourea Derivatives as Potential Chemotherapeutic Agents: Synthesis, Structural Insights, and Antimicrobial/Anti-Proliferative Profiles

FAM Al-Omary, N Alvarez, LS Al-Rasheed, N Veiga… - ACS …, 2023 - ACS Publications
… In this study, two adamantane-linked isothiourea derivatives containing a common 4-…
of the adamantane/isothiourea combination to render auspicious scaffolds for new potential …