Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
… The major instigating factor for the immune response in celiac disease is the activation of …
response to stimulation in gsTcells. Recently, it was shown that the genetic risk loci associated …
response to stimulation in gsTcells. Recently, it was shown that the genetic risk loci associated …
An updated overview on celiac disease: from immuno-pathogenesis and immuno-genetics to therapeutic implications
P D'Avino, G Serena, V Kenyon… - Expert review of clinical …, 2021 - Taylor & Francis
… plays in celiac disease as well as new proposed therapies and … • Immune response
characterizing celiac disease pathogenesis is complex and each step, from innate immune response …
characterizing celiac disease pathogenesis is complex and each step, from innate immune response …
New insights on genes, gluten, and immunopathogenesis of celiac disease
… due to a low number of individuals tested. Additional CeD genetic risk variants related to
the immune response were further identified through the genotyping of the most strongly …
the immune response were further identified through the genotyping of the most strongly …
[HTML][HTML] Celiac disease: From genetics to epigenetics
E Gnodi, R Meneveri, D Barisani - World journal of …, 2022 - ncbi.nlm.nih.gov
… SNPs involved genes with an immune function either in the … of many risk variants common
to other autoimmune diseases, … vivo and in vitro, through the newly identified axis IL-15/STAT3/…
to other autoimmune diseases, … vivo and in vitro, through the newly identified axis IL-15/STAT3/…
Genome-wide association study-guided exome rare variant burden analysis identifies IL1R1 and CD3E as potential autoimmunity risk genes for celiac disease
H Mansour, B Banaganapalli, KK Nasser… - Frontiers in …, 2022 - frontiersin.org
… Celiac disease (CeD) is a multifactorial autoimmune … overactivation of the immune system in
response to dietary gluten. … new disease causal genes for many complex diseases (38). This …
response to dietary gluten. … new disease causal genes for many complex diseases (38). This …
Genotypes predisposing for celiac disease and autoimmune diabetes and risk of infections in early childhood
… autoimmunity and clinical disease 3 and recently also CD. … risk variants seem to influence
regulatory regions of immunity. … to induce interferon response and other immune reactions that …
regulatory regions of immunity. … to induce interferon response and other immune reactions that …
Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes
JXM Cerqueira, P Saavalainen, K Kurppa… - … of Human Genetics, 2021 - nature.com
… cause a systemic immune response in healthy individuals, … The genotypes of 94 coeliac
disease risk variants [5, 6] were … for identifying new coeliac disease SNPs associated with the …
disease risk variants [5, 6] were … for identifying new coeliac disease SNPs associated with the …
Immunochip meta-analysis in European and Argentinian populations identifies two novel genetic loci associated with celiac disease
, … study of genetic associations of celiac disease … - … of Human Genetics, 2020 - nature.com
… to identify new loci contributing to CeD by increasing the sample size (adding >4000 new
samples) … We then used a system genetics approach to identify new pathways playing a role in …
samples) … We then used a system genetics approach to identify new pathways playing a role in …
Beyond the HLA genes in gluten-related disorders
M Sallese, LR Lopetuso, K Efthymakis, M Neri - Frontiers in Nutrition, 2020 - frontiersin.org
… with the celiac disease. We recently identified differentially expressed genes and miRNAs
in … It has also been reported that risk variants in the IL2-IL21 region may further contribute to …
in … It has also been reported that risk variants in the IL2-IL21 region may further contribute to …
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease
A Van der Graaf, MM Zorro, A Claringbould… - … in Genetics, 2021 - frontiersin.org
… In three out of four co-regulation clusters, we find shared immune function. For instance,
STAT1, CD274, and IL12A are in the same cluster and are all involved in IFNγ and IL-6 signaling…
STAT1, CD274, and IL12A are in the same cluster and are all involved in IFNγ and IL-6 signaling…