… The major instigating factor for the immune response in celiac disease is the activation of …
response to stimulation in gsTcells. Recently, it was shown that the genetic risk loci associated …

… plays in celiac disease as well as new proposed therapies and … • Immune response
characterizing celiac disease pathogenesis is complex and each step, from innate immune response …

… due to a low number of individuals tested. Additional CeD genetic risk variants related to
the immune response were further identified through the genotyping of the most strongly …

… SNPs involved genes with an immune function either in the … of many risk variants common
to other autoimmune diseases, … vivo and in vitro, through the newly identified axis IL-15/STAT3/…

… Celiac disease (CeD) is a multifactorial autoimmune … overactivation of the immune system in
response to dietary gluten. … new disease causal genes for many complex diseases (38). This …

… autoimmunity and clinical disease 3 and recently also CD. … risk variants seem to influence
regulatory regions of immunity. … to induce interferon response and other immune reactions that …

… cause a systemic immune response in healthy individuals, … The genotypes of 94 coeliac
disease risk variants [5, 6] were … for identifying new coeliac disease SNPs associated with the …

… to identify new loci contributing to CeD by increasing the sample size (adding >4000 new
samples) … We then used a system genetics approach to identify new pathways playing a role in …

… with the celiac disease. We recently identified differentially expressed genes and miRNAs
in … It has also been reported that risk variants in the IL2-IL21 region may further contribute to …

… In three out of four co-regulation clusters, we find shared immune function. For instance,
STAT1, CD274, and IL12A are in the same cluster and are all involved in IFNγ and IL-6 signaling…