… This sequence of events results from mutations in the CFTR gene and leads to cystic fibrosis
(CF). More than 90% of CF patients have at least one allele leading to the expression of p.…

… maintain ASL homeostasis. One strategy to restore ASL volume in CF airway surfaces is to
… Cells were incubated overnight under oscillatory shear stress that mimics the phasic motion …

… The airway surface liquid (ASL) under resting conditions is … volume homeostasis. First,
there is a basal secretion of the … and 2) shear on airway surfaces due to phasic airflow (FIGURE …

… understanding of the airway surface organization by describing … mucous layer juxtaposed to
airway cell surface-tethered mucins… shear stress, behaves as a viscous liquid; thus, the shear …

… velocity, which exerts shearing forces on the mucus located on the airway surface. Modifying
the … Nucleotide release provides a mechanism for airway surface liquid homeostasis. J Biol …

… fluid secretion and airway surface liquid height in CF-HBE cells under both static conditions
and conditions designed to mimic the shear … of ion transport and fluid homeostasis (29, 30) (…

… When the hydration of the airway surface liquid (ASL) … phasic motion that mimics the shear
stress that is associated with … CALHM 1 [Ca 2+ homeostasis modulator 1] exhibited reduced …

… and nucleosides within the airway surface liquid (ASL), and … systems that maintain ASL
homeostasis. The efficacy of P2Y 2 … at an air–liquid interface overnight under phasic motion (0.5 …

… cell types expressing CFTR (cystic fibrosis [CF] transmembrane … expression in normal
human airway epithelia is missing. … ) function disrupts airway surface liquid (ASL) homeostasis, …

… that are vital for normal airway homeostasis but, when their … state of mucus at the airway
surface, impair mucociliary clearance … is critical to maintain the airway surface liquid (ASL) at an …