Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans
NK Oliveira, S Bhattacharya, R Gambhir, M Joshi… - Journal of Fungi, 2022 - mdpi.com
Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals,
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can
lead to azole resistance, which can be mediated by overexpression of ABC transporters, a
class of efflux pumps. ABC pump-mediated efflux of FLC is also augmented in 10-generation
old C. neoformans cells. Here, we describe a new ABC transporter Afr3 (CNAG_06909),
which is overexpressed in C. neoformans cells of advanced generational age that …
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can
lead to azole resistance, which can be mediated by overexpression of ABC transporters, a
class of efflux pumps. ABC pump-mediated efflux of FLC is also augmented in 10-generation
old C. neoformans cells. Here, we describe a new ABC transporter Afr3 (CNAG_06909),
which is overexpressed in C. neoformans cells of advanced generational age that …
[PDF][PDF] Novel ABC Transporter Associated with Fluconazole Resistance in Aging of Cryptococcus neoformans. J. Fungi 2022, 8, 677
NK Oliveira, S Bhattacharya, R Gambhir, M Joshi… - 2022 - academia.edu
Cryptococcus neoformans causes meningoencephalitis in immunocompromised individuals,
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can
lead to azole resistance, which can be mediated by overexpression of ABC transporters, a
class of efflux pumps. ABC pump-mediated efflux of FLC is also augmented in 10-generation
old C. neoformans cells. Here, we describe a new ABC transporter Afr3 (CNAG_06909),
which is overexpressed in C. neoformans cells of advanced generational age that …
which is treated with fluconazole (FLC) monotherapy when resources are limited. This can
lead to azole resistance, which can be mediated by overexpression of ABC transporters, a
class of efflux pumps. ABC pump-mediated efflux of FLC is also augmented in 10-generation
old C. neoformans cells. Here, we describe a new ABC transporter Afr3 (CNAG_06909),
which is overexpressed in C. neoformans cells of advanced generational age that …
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