… control the ERα signaling activity, is critical for developing novel therapeutics for breast cancer.
… E3 ubiquitin ligase, we further investigate the role of RNF181 on ERα ubiquitination. The …

… E3 ligases (18, 19). In contrast, acetylation of SNAIL prevents its recognition by E3 ubiquitin
ligases … of EMT and metastasis of triple-negative breast cancer (TNBC) cells driven by the …

… ubiquitination and protein stability. Here, we report that RNF187, a RING family ubiquitin
ligase, facilitates breast cancer … Our findings revealed not only a novel E3 ligase regulator of …

… To further understand the pathophysiological role of SCF E3 ubiquitin ligase in BRCA, we
… BRCA tissues (n = 60, with 30 breast carcinoma tissues and 30 normal tissue counterparts) (…

… TRIM family members have been shown to exhibit E3 ubiquitin ligase activity that …
ubiquitination. Overall, our results outline a novel regulatory mechanism governing the ubiquitination …

… It has been recently reported that the deubiquitinase USP9X and RNF115 are correlatively
upregulated in breast cancer tissue arrays and breast cancer cell lines (37). USP9X interacts …

… E3 ubiquitin ligase, thereby stimulating the targeted protein degradation via the UPS. Hence,
PROTACs have emerged as a promising alternative to control the pro-tumor effect of ERα …

… effects of HL435 on breast cancer, we performed flow … The ability of apoptosis induction by
HL435 in breast cancer … significantly down-regulated in breast cancer cells treated with HL435…

… will be discovered and developed as a novel class of anticancer drugs in the foreseeable
future, we are still facing significant challenges so far. Firstly, the specific substrate of …

… ubiquitination and degradation 37 . In our study, we identified RNF187 as a novel E3 ligase
… signaling by inducing YAP K48-linked ubiquitination and degradation. This finding provides …