… UBR5 amplification in mRNA levels has been demonstrated in ovarian and breast cancer
[53] . … As a novel ubiquitin ligase for the proapoptotic protein modulator of apoptosis protein 1 (…

… However, high expression levels of HuR may also have a favorable prognostic value, eg,
for breast cancer 65 , which may be associated with HuR-mediated stabilization of p53 and …

… breast cancer cells, while co-immunoprecipitation (coIP) was performed to identify the E3
ubiquitin ligase … High expression of TRIM27 was found in non-triple-negative breast cancer (non…

… the CRL4 DDB2 E3 ubiquitin ligase assembly, resulting in p27 ubiquitination and BC …
revealed a novel interaction between circPFKFB4 and the CRL4 DDB2 E3 ubiquitin ligase, …

… is a RING finger E3 ubiquitin ligase and is a poor prognostic factor in breast cancer patients.
… , a region amplified in up to 40% of breast cancers. We observed that activation of androgen …

… cancer, deletion in gene enoding parkin RBR E3 ubiquitin protein ligase [PARK2] in ovarian,
bladder, and breast cancer) … glue are novel strategies to target E3 ligases. PROTACs are bi-…

… Further studies targeting specific E2-E3 pairing in breast carcinoma are critical for the … (iii)
KPG-818 is a novel modulator of the CRBN E3 ubiquitin ligase complex CRL4 CRBN . CRL4 …

… RING E3 ubiquitin ubiquitin ligases function as scaffolds that bring the E2–ubiquitin …
SMURF2 has been shown to be a novel regulator in breast cancer, as overexpressed SMURF2 in …

… several cancers, including breast cancer 15 , prostate cancer 13 , gastric … novel therapeutic
targets for human cancers. In the current study, we focused on the role of E3 ubiquitin ligases …

… regulated by posttranscriptional modifications such as ubiquitination in breast cancer cells.
Recent work also suggests that BRCA1 serves as a novel HUWE1-interacting substrate that …