… , as a novel driver of cell-cycle progression in breast cancer. NNMT, highly expressed in …
of Cullin-1-RING E3 ubiquitin ligase(CRL1)—an E3 ubiquitin ligase targeting p27 proteins. …

… In fact, MARCH5 can be found upregulated in breast cancer (BC): high levels of the ligase
have … Thus, E3 ligases such as RNF185 may represent a novel target for glioblastoma therapy …

… of breast cancer and PERP was identified as a novel substrate of CRL4 DCAF13 E3 ligase.
… that PERP could be recognized and ubiquitinated by CRL4 DCAF13 E3 ubiquitin ligase. Co-…

… a considerable rate of breast cancer patients, and novel drug therapies are … E3 ubiquitin
ligase, and SIAHs are involved in cancers such as prostate cancer, leukemia, and breast cancer. …

… Additionally, considering the potential of E3 ligases as novel targets in the treatment … E3
ubiquitin ligases has been confirmed in many cancers, including breast cancer, ovarian cancer …

… There are many E3 ubiquitin ligases in our bodies, which … However, PROTAC can only
hijack less than 1% of E3 ligases in … VHL or CRBN as the E3 ligase due to the presence of their …

… (MOM) with the RING structural domain exposed in the … membrane-associated ring-finger
E3 ubiquitin ligase. Its main … with the prognosis of breast cancer patients confirmed in multiple …

… the ubiquitination degradation of JAK2 protein through activation of the E3 ubiquitin ligase
… C, and Rbx2 to form a functional CRL5 E3 ligase, which then binds to the substrate protein …

… E3 ligases and revealed their relationship with cancer, which is of great significance for
discovering novel drug targets of cancer … suppress oncogene-driven breast cancer. The tyrosine …

… BRCA1 in the nucleus is involved in genomic stability by regulating DNA repair, cell- cycle
checkpoints, and E3 ubiquitin ligase activity, which are the main functions of BRCA1 as a …