… novel oncogenic drivers to provide new therapeutic targets? Second, can we identify patients
who are most likely to respond to current therapeutic … remains for biomarkers to optimize …

… a potential therapeutic target, MITF … biomarkers able to select patients who are more likely
or unlikely to benefit from a given therapy in advance of its initiation would allow for optimizing …

… and exploit molecular targets to optimize clinical outcomes for patients with melanoma. …
, emerging drug targets, and the potential for combination therapies for non-BRAF V600 …

… patients possess somatic (31.6%) or germline (TCGA: 4.2%; registry: 8.3%) mutations in
homologous recombination (HR) repair genes, which may serve as a therapeutic target. The …

… In addition, novel oncogenic drivers should be discovered to provide new therapeutic targets.
Current methods of detection, prognosis and monitoring of melanoma are based on clinical…

… in melanoma treatment. Considering the relevance of the immune infiltrate in supporting
melanoma … immune cell activity, identifying interesting therapeutic options that may support the …

… The discovery of novel targets and strategies is imperative to … targeted therapies in melanoma.
This review will discuss various therapeutic targets and inhibitors used to treat melanoma, …

… melanoma cells and that the inhibition of both proteins alters cell invasion capability representing
a possible therapeutic target [… therapies, either minimizing side effects and optimizing …

… Very recently, immune evasion by cancer cells has become an important therapeutic target
[2]. … for the development of novel therapeutic strategies or for the optimization of the efficacy of …

… was optimised by Heloise Halse for melanoma, Dr Kelly Waldeck optimised the protocol for
MCC and I optimised the … , and signalled the immune system as a potential therapeutic target. …