… for ketone body generation from fatty acids and amino acids [… in another two AD mouse
models, ie, APP/PS1 and 3xTg-AD, … glycolysis and TCA cycle, all of which adversely impact …

… ), APP/PS1 mice, 3xTg-AD (triple-transgenic mouse model … of ketone bodies and has a
lasting cognition-improving effect in … bypass of the glycolytic pathway [86, 173, 188]. In the brain, …

… approaches that produce ketone bodies for energy metabolism, … , 5xFAD mice fed a 4-month
KD had reduced hippocampal Aβ … 3xTg-AD mice fed an 8-month 43.5% carbohydrate diet …

… safe ketone body precursors for the treatment of diseases in … of energy metabolism/glycolysis
and nucleotide, protein, as well as … For example, hippocampal upregulation of miR-181 and …

… safe ketone body precursors for the treatment of diseases in … of energy metabolism/glycolysis
and nucleotide, protein, as well … c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J. …

… by regulating the tricarboxylic acid cycle (TCA) and glycolytic … and hippocampal brain regions
and platelets of patients [4,5]. … in cortical neurons of 3xTg-AD or APPsw mice [131]. An age-…

… to decreased ATP levels and increased glycolytic production of ATP, … enzymatic activities
and intermediates to assess TCA and … synthase kinase 3beta in primary cultured hippocampal …