… of neuroinflammation imaging with (R)-[ 11 C]PK11195 (… first systematic review of these
“(R)-[ 11 C]PK11195 challengers”, … a number of detailed reviews [32,33,34], no meta-analysis is …

… radiolabeling is a complex process, and the half-life of carbon-11 is just 20 min long; thus,
[ 11 C]-PK11195 could only be used in PET centers equipped with cyclotrons [16]. Second, [ …

… ligand PK11195 that could be radiolabelled with [ 11 C] led to a long series of positron
emission tomography (PET) investigations in a broad range of neurological conditions [7,8,9,10,…

… on the synthesis of [ 11 C]PK11195, which is structurally related to [ 11 C]ER176. Cleij et
al.(… with [ 11 C]PK11195 and found it to be a hydro-des-chloro analog of des-methyl-PK11195, …

… in TSPO density makes [ 11 C](R)-PK11195 unsuitable for nuclear imaging in some diseases
[69]. Despite these limitations, [ 11 C](R)-PK11195 shows remarkably low sensitivity to …

… [ 11 C]PK11195-positron emission tomography (PET) imaging has been used to
visualize neuroinflammation; … (SPECT) imaging is potentially more practical than [ 11 C]PK11195-PET …

… 11 C]PK11195 has hampered development of a standard method for quantitative data
analysis… It has been demonstrated that CB2 is strongly overexpressed during neuroinflammation. …

… inflammatory targets, PET imaging of neuroinflammation is at a particularly promising stage.
This Review critically evaluates PET imaging results of inflammation in psychiatric disorders, …

… [ 11 C]PK11195 is the first tracer used in neuroinflammatory PET imaging studies. Although
it has been studied for more than 20 years, [ 11 C]PK11195 still has many limitations: the …

… showed a reduced synaptic density in [11C]UCB-J PET, linked [11C]PK11195 and [18F]AV-…
of [11C]PK11195 PET imaging, shedding light on both neuroinflammatory components and …