Safety of ocrelizumab in patients with relapsing and primary progressive multiple sclerosis

SL Hauser, L Kappos, X Montalban, L Craveiro… - Neurology, 2021 - AAN Enterprises
… in phase 2 and 3 studies, leading to the approval of OCR for the treatment of patients with
relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). …

… the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo …

JS Wolinsky, DL Arnold, B Brochet, HP Hartung… - The Lancet …, 2020 - thelancet.com
… switching from placebo, earlier and continuous ocrelizumab treatment … ocrelizumab in
primary progressive disease, progression remains an important unmet need in multiple sclerosis. …

Real‐world results of ocrelizumab treatment for primary progressive multiple sclerosis

K Daniels, PB van der Nat, S Frequin… - Multiple sclerosis …, 2020 - Wiley Online Library
ocrelizumab (Ocrevus®) was approved for the treatment of primary progressive multiple
sclerosis (… Real-world data about the clinical effectiveness of ocrelizumab has yet to be gathered. …

Effect of ocrelizumab in blood leukocytes of patients with primary progressive MS

JI Fernández-Velasco, J Kuhle, E Monreal… - Neurology …, 2021 - AAN Enterprises
… However, in about 10% of the cases, the disease starts with a progressive disability worsening
without remission periods. This form of the disease is known as primary progressive MS (…

Relapsing-remitting and primary progressive multiple sclerosis treated with ocrelizumab: a comparative study

LAR de Antonio, I Cuberta-Gonzalez… - Multiple Sclerosis and …, 2023 - Elsevier
… To compare the clinical and radiological effectiveness of ocrelizumab in primary progressive
multiple sclerosis (PPMS) and relapsing-remitting multiple sclerosis (RRMS) in a clinical …

[HTML][HTML] Ocrelizumab in patients with active primary progressive multiple sclerosis: clinical outcomes and immune markers of treatment response

M Boziki, C Bakirtzis, SA Sintila, E Kesidou, E Gounari… - Cells, 2022 - mdpi.com
… active primary progressive multiple sclerosis (PPMS) were included in this prospective,
uncontrolled, open-label, observational study. All patients were followed by the Multiple Sclerosis

Ocrelizumab in relapsing and primary progressive multiple sclerosis: pharmacokinetic and pharmacodynamic analyses of OPERA I, OPERA II and ORATORIO

E Gibiansky, C Petry, F Mercier… - British journal of …, 2021 - Wiley Online Library
Ocrelizumab is a humanized monoclonal antibody that selectively targets CD20-positive
B … relapsing forms of multiple sclerosis (RMS) or primary progressive multiple sclerosis (PPMS). …

Effectiveness of ocrelizumab in primary progressive multiple sclerosis: a multicenter, retrospective, real-world study (OPPORTUNITY)

CG Chisari, A Bianco, VB Morra, M Calabrese… - …, 2023 - Elsevier
Ocrelizumab is a recombinant humanized monoclonal … effect of ocrelizumab on primary
progressive multiple sclerosis (… We aimed to assess the clinical effectiveness of ocrelizumab in …

Effectiveness of rituximab vs. ocrelizumab for the treatment of primary progressive multiple sclerosis: a real-world observational study

C Alcalá, C Quintanilla-Bordás, F Gascón… - Journal of …, 2022 - Springer
Ocrelizumab, an antiCD-20 antibody, is the only drug approved to treat patients with primary
progressive multiple sclerosis (pwPPMS). Not all candidates receive this treatment due to …

Ocrelizumab for treating patients with primary progressive multiple sclerosis: an evidence review group perspective of a NICE single technology appraisal

P Auguste, J Colquitt, M Connock, E Loveman… - …, 2020 - Springer
… Clinical evidence for ocrelizumab in primary progressive multiple sclerosis (PPMS) came
from a randomised controlled trial. From this trial, the European Medical Agency label …