… on their ability to inhibit aggregation of amyloid β, tau, and α-… ability to reduce oligomeric
tau toxicity in mammalian cells. … (170) In addition, OLEA is involved with the amelioration of …

… evaluated in primary neuron cultures originated from the AD-type amyloidβ … , oleocanthal
and HT inhibit toxic aggregation of tau(70). … In SH-SY5Y neuronal cells, resveratrol ameliorates …

… , and in case of failure in astrocytesneurons interaction, this could result in astrocytes …
activation of astrocytes neglect the neuroprotective role in AD and expose neurons to toxic insults (…

… AD, increase in amyloid β peptide deposition and uncontrolled … (4-week) of oleocanthal
secoiridoid was studied in TgSwDI … reduced the astrocyte and microglial activation in brain cells, …

… by the deposition and accumulation of amyloid-β (Aβ) in the … , such as oleuropein aglycone,
oleocanthal, and hydroxytyrosol, … reduced astrocyte activation and ameliorated the astrocyte …

… Various types of cells, including microglia, astrocytes, and … The deposition of misfolded
amyloid-β (Aβ) in the brain is a … Oleocanthal (OC), a phenolic compound abundant in EVOO, …

… brain homeostasis by removing toxic peptides and compounds… in many cell types including
astrocytes, microglia, neurons, … Other disorders in which the effects of oleocanthal have been …

… For example, oleocanthal (OC) is cytotoxic to human melanoma cells, but not to normal dermal
… In murine astrocytes, OC ameliorated toxicity of amyloid-β oligomers, reducing astrocyte …

Extra virgin olive oil (EVOO) polyphenols, including the secoiridoids oleocanthal (OLC) and
oleacein (OLE), are attracting attention because of their beneficial effects on health. Data on …

… Harpagoside ameliorates the amyloid-β-induced cognitive … Each glial cell, including microglia
and astrocytes, play a … The use of a phenolic component of olive oil called oleocanthal in …