Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies
JPW Heidbuechel, CE Engeland - Journal of hematology & oncology, 2021 - Springer
… On-target off-tumor toxicity as a safety concern of redirecting … slices derived from prostate
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…
cancer biopsies. Following virus … an oncolytic adenovirus encoding a FAP-TAc (T cell activator…
[HTML][HTML] Bispecific T cell engagers and their synergistic tumor immunotherapy with oncolytic viruses
Q Huang, WQ Cai, ZW Han, MY Wang… - … Journal of Cancer …, 2021 - ncbi.nlm.nih.gov
… less cytotoxic to non-cancer cells but increase their ability to … The replication of oncolytic
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …
adenovirus in tumor cells is strictly … T cells in liquid cancer biopsy samples without additional …
Bi-and tri-specific T cell engager-armed oncolytic viruses: next-generation cancer immunotherapy
… supported bystander cell-mediated cytotoxicity. In two distinct … Indeed, treatment of fresh
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …
clinical biopsies, including … This FBiTE was inserted in the oncolytic adenovirus ICOVIR15K …
Oncolytic adenovirus in cancer immunotherapy
M Peter, F Kühnel - Cancers, 2020 - mdpi.com
… The goal of this review is to provide an introduction into the … T cells to cancer cells are
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …
bispecific T-cell engagers (BiTEs) [… T-cell cytotoxicity against M2-TAMs in cancer patient biopsies, …
Oncolytic adenoviruses for cancer therapy
… to induce oncolytic effects and a tumor-specific cytotoxic T-… target antigens triggers T-cell
activation leading to target cell … microenvironment of liquid cancer biopsies (malignant …
activation leading to target cell … microenvironment of liquid cancer biopsies (malignant …
Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer
Q Wang, X Ma, H Wu, C Zhao, J Chen, R Li… - …, 2022 - Taylor & Francis
… cancer (OC) is related to the action of infiltrating cytotoxic T … In this study, we tested the
hypothesis that bispecific T-cell … in the biopsy of all tested patients tested positive for PD1 …
hypothesis that bispecific T-cell … in the biopsy of all tested patients tested positive for PD1 …
[PDF][PDF] CANCER IMMUNOTHERAPY WITH ONCOLYTIC VIRUSES ARMED WITH CYTOKINES AND FUSION PROTEINS
S Basnet - helda.helsinki.fi
… of oncolytic adenoviruses (OAds) coding for human Mucin1 (MUC1) T cell engager intending
to increase T cell-… In the virus-treated group, stimulated T cell cytotoxicity was detected …
to increase T cell-… In the virus-treated group, stimulated T cell cytotoxicity was detected …
Oncolytic vaccinia virus expressing a bispecific T-cell engager enhances immune responses in EpCAM positive solid tumors
M Wei, S Zuo, Z Chen, P Qian, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
… primary T cell activation and T cell-mediated cytotoxicity … Fajardo et al. engineered an
oncolytic adenovirus, ICOVIR-… the efficacy of OV-BiTE in cancer biopsies. However, the lack of a …
oncolytic adenovirus, ICOVIR-… the efficacy of OV-BiTE in cancer biopsies. However, the lack of a …
Role of adenoviruses in cancer therapy
ST Tseha - Frontiers in Oncology, 2022 - frontiersin.org
… with oncolytic adenoviruses. In order to improve the efficacy of the CAR-T cell therapy, this
… The Tri-Ad vaccine regimen induces antitumor cytotoxic T cell (CTL) responses and was …
… The Tri-Ad vaccine regimen induces antitumor cytotoxic T cell (CTL) responses and was …
[HTML][HTML] Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy
C Groeneveldt, P Kinderman… - … of Cancer, 2020 - ncbi.nlm.nih.gov
… T-cell-engaging bispecific antibodies (bsAbs) are emerging as a … in xenograft models and
an oncolytic adenovirus encoding a CD3-… So-called “on-target, off-tumor toxicity” might limit the …
an oncolytic adenovirus encoding a CD3-… So-called “on-target, off-tumor toxicity” might limit the …