One-pot synthesis of poly (alkyl methacrylate)-functionalized mesoporous silica hybrid nanocomposites for microencapsulation of poorly soluble phytochemicals
M Shafiee, SS Abolmaali, AM Tamaddon… - Colloid and Interface …, 2020 - Elsevier
Silibinin (SBN), the major active constituent of milk thistle seeds indicated in liver conditions,
has low oral bioavailability due to low solubility and degradation in gastric fluid. Hybrid
mesoporous silica nanocomposites composed of polymerized alkyl methacrylate monomers
(methyl methacrylate, butyl methacrylate or 1: 1 mixture of methyl methacrylate and acrylic
acid) were developed to enhance dissolution and antioxidant activity of SBN. Samples were
worked up by calcination in oven or refluxing with ammonium nitrate. DLS, FE-SEM, AFM …
has low oral bioavailability due to low solubility and degradation in gastric fluid. Hybrid
mesoporous silica nanocomposites composed of polymerized alkyl methacrylate monomers
(methyl methacrylate, butyl methacrylate or 1: 1 mixture of methyl methacrylate and acrylic
acid) were developed to enhance dissolution and antioxidant activity of SBN. Samples were
worked up by calcination in oven or refluxing with ammonium nitrate. DLS, FE-SEM, AFM …
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