Female rats self-administer heroin by vapor inhalation

A Gutierrez, JD Nguyen, KM Creehan… - … Biochemistry and Behavior, 2020 - Elsevier
… The anti-nociceptive effect of heroin self-administered by vapor was identical in magnitude
to that produced by intravenous self-administration. Finally, anxiety-like behavior increased 24…

Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction

CB Pantazis, LA Gonzalez, BJ Tunstall… - Science …, 2021 - science.org
… A plausible explanation for this finding is that rats self-administeredprocess, generated
increasingly elevated brain reward thresholds during withdrawal. Although rats self-administered

Ranking the contribution of behavioral measures comprising oxycodone self-administration to reinstatement of drug-seeking in male and female rats

SK Guha, Y Alonso-Caraballo, GS Driscoll… - Frontiers in Behavioral …, 2022 - frontiersin.org
… Test in male and female rats that had self-administered oxycodone in the escalation phase
under LgA or ShA conditions or self-administered saline (Sal). Across treatment groups, …

Enhanced Female Vulnerability to Cocaine Self-Administration

MI Mauterer - 2022 - search.proquest.com
… 62 Lynch, WJ, Roth, ME, Mickelberg, JL & Carroll, ME Role of estrogen in the acquisition
of intravenously self-administered cocaine in female rats. Pharmacol Biochem Behav 68, 641-…

Cocaine abuse and midbrain circuits: Functional anatomy of hypocretin/orexin transmission and therapeutic prospect

SJ Simmons, TA Gentile - Brain research, 2020 - Elsevier
cocaine use including depression-like behavior and anhedonia. Rats subjected to intermittent
cocaine … in reducing demand elasticity for self-administered cocaine. Other work by this …

Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement

J Palandri, SL Smith, DJ Heal… - Journal of …, 2021 - journals.sagepub.com
Background: α7 Nicotinic acetylcholine receptors are implicated in the reinstatement of drug-seeking,
an important component of relapse. We showed previously that the α7 nicotinic …

… binding at the Zfp189 promoter within medium spiny neuron subtypes differentially regulates behavioral and physiological adaptations over the course of cocaine use

CD Teague, JA Picone, WJ Wright, CJ Browne… - Biological …, 2023 - Elsevier
… induction of Zfp189 in the NAc self-administered more cocaine infusions than mice with G9a
… in an opponent process that is differentially balanced over the course of cocaine experience…

Circadian-dependent and sex-dependent increases in intravenous cocaine self-administration in Npas2 mutant mice

LM DePoy, DD Becker-Krail, W Zong… - Journal of …, 2021 - Soc Neuroscience
… sessions of descending unit doses of cocaine (1.0, 0.5, 0.25, 0.125, … properties of cocaine,
which will be described throughout as reinforcement.. Next, mice self-administered cocaine at …

The effects of cocaine and heroin polydrug use on drug-related motivation and affective state in Lister-Hooded rats

K Adamatzky - 2023 - sussex.figshare.com
… motivational and hedonic effects of sequential cocaine and heroin use by recording …
Cocaine consumption increased at a higher rate than heroin and total consumption of cocaine

3d synaptic organization of the rat CA1 and alterations induced by cocaine self-administration

L Blázquez-Llorca, M Miguéns… - Cerebral …, 2021 - academic.oup.com
… Rats that self-administered cocaine progressively increased the number of infusions
received and the number of times the lever was pressed with respect to the saline group (whose …