Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part I: Cattle and swine

Z Lin, M Li, YS Wang, LA Tell… - Journal of veterinary …, 2020 - Wiley Online Library
… food-producing species, including goats, sheep, chickens, and turkeys. The ultimate … organ
weights and blood flows to organs were calculated into organ weight fractions and blood flow

[HTML][HTML] Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep

LS Lautz, J Dorne, R Oldenkamp, AJ Hendriks… - Toxicology letters, 2020 - Elsevier
… Parameters were collected for organ weights and blood flows in all … 29, 48 and 33 for cattle,
sheep, and swine, respectively. … blood flow parameter values were available for juvenile pigs (…

[HTML][HTML] Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep

LS Lautz, S Hoeks, R Oldenkamp, AJ Hendriks… - Toxicology Letters, 2020 - Elsevier
… Generic PBK models integrate physiological and anatomical … (ie organ volumes), connected
through blood flow, chemical … body weight (BW), cardiac output (CO) and renal blood flow (…

… of an interactive physiologically based pharmacokinetic (iPBPK) model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep and …

MH Riad, RE Baynes, LA Tell, JL Davis… - Toxicological …, 2021 - academic.oup.com
… This study focuses on developing a physiologically based pharmacokinetic (PBPK) model
… ), relative organ weights (ie, percent of body weight), and the fraction of blood flow to organs/…

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part II: Chicken and turkey

YS Wang, M Li, LA Tell, RE Baynes… - Journal of veterinary …, 2021 - Wiley Online Library
organ weights (% of body weight) and relative blood flows (… to the total of beef and pork
production. In 2018, broiler chickens … for growing turkeys, as well as sheep (Ovis aries) and goats (…

A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs

K Mi, L Sun, Y Hou, X Cai, K Zhou, W Ma… - PLoS Computational …, 2023 - journals.plos.org
… interstitial fluid and cells of organs, which are thought to comprise blood, interstitial fluid,
and … The PBPK model in this study is based on piglets with a body weight of about 25 kg (these …

Understanding volume kinetics: the role of pharmacokinetic modeling and analysis in fluid therapy

XT Yiew, SW Bateman, RG Hahn… - Frontiers in Veterinary …, 2020 - frontiersin.org
… compartmental model, the compartments do not represent a specific organ or fluid … Sheep
and pigs are common biomedical research models for the study of major human physiological

Application of physiologically based pharmacokinetic models to promote the development of veterinary drugs with high efficacy and safety

K Zhou, K Mi, W Ma, X Xu, M Huo… - Journal of Veterinary …, 2021 - Wiley Online Library
organs have no physiological barrier, the perfusion-limited model is the most commonly used
model; … What we can image is that for an intramuscular preparation of pigs if its single dose …

A physiology-based pharmacokinetic framework to support drug development and dose precision during therapeutic hypothermia in neonates

A Smits, P Annaert, S Van Cruchten… - Frontiers in …, 2020 - frontiersin.org
… the blood compartment, drugs will be distributed to other organs … in Animal Models), the
newborn conventional piglet is … of animal models, including cats, dogs, guinea pigs, sheep, …

Quantitative comparison of avian and mammalian physiologies for parameterization of physiologically based kinetic models

CG Scanes, J Witt, M Ebeling, S Schaller… - … in physiology, 2022 - frontiersin.org
… Moreover, linear regression was employed to analyze allometric relationships between
relative organ weight (organ weight as a percentage of body weight) and log 10 body …