Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part I: Cattle and swine
… food-producing species, including goats, sheep, chickens, and turkeys. The ultimate … organ
weights and blood flows to organs were calculated into organ weight fractions and blood flow …
weights and blood flows to organs were calculated into organ weight fractions and blood flow …
[HTML][HTML] Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep
… Parameters were collected for organ weights and blood flows in all … 29, 48 and 33 for cattle,
sheep, and swine, respectively. … blood flow parameter values were available for juvenile pigs (…
sheep, and swine, respectively. … blood flow parameter values were available for juvenile pigs (…
[HTML][HTML] Generic physiologically based kinetic modelling for farm animals: Part II. Predicting tissue concentrations of chemicals in swine, cattle, and sheep
… Generic PBK models integrate physiological and anatomical … (ie organ volumes), connected
through blood flow, chemical … body weight (BW), cardiac output (CO) and renal blood flow (…
through blood flow, chemical … body weight (BW), cardiac output (CO) and renal blood flow (…
… of an interactive physiologically based pharmacokinetic (iPBPK) model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep and …
… This study focuses on developing a physiologically based pharmacokinetic (PBPK) model
… ), relative organ weights (ie, percent of body weight), and the fraction of blood flow to organs/…
… ), relative organ weights (ie, percent of body weight), and the fraction of blood flow to organs/…
Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part II: Chicken and turkey
… organ weights (% of body weight) and relative blood flows (… to the total of beef and pork
production. In 2018, broiler chickens … for growing turkeys, as well as sheep (Ovis aries) and goats (…
production. In 2018, broiler chickens … for growing turkeys, as well as sheep (Ovis aries) and goats (…
A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs
K Mi, L Sun, Y Hou, X Cai, K Zhou, W Ma… - PLoS Computational …, 2023 - journals.plos.org
… interstitial fluid and cells of organs, which are thought to comprise blood, interstitial fluid,
and … The PBPK model in this study is based on piglets with a body weight of about 25 kg (these …
and … The PBPK model in this study is based on piglets with a body weight of about 25 kg (these …
Understanding volume kinetics: the role of pharmacokinetic modeling and analysis in fluid therapy
XT Yiew, SW Bateman, RG Hahn… - Frontiers in Veterinary …, 2020 - frontiersin.org
… compartmental model, the compartments do not represent a specific organ or fluid … Sheep
and pigs are common biomedical research models for the study of major human physiological …
and pigs are common biomedical research models for the study of major human physiological …
Application of physiologically based pharmacokinetic models to promote the development of veterinary drugs with high efficacy and safety
K Zhou, K Mi, W Ma, X Xu, M Huo… - Journal of Veterinary …, 2021 - Wiley Online Library
… organs have no physiological barrier, the perfusion-limited model is the most commonly used
model; … What we can image is that for an intramuscular preparation of pigs if its single dose …
model; … What we can image is that for an intramuscular preparation of pigs if its single dose …
A physiology-based pharmacokinetic framework to support drug development and dose precision during therapeutic hypothermia in neonates
A Smits, P Annaert, S Van Cruchten… - Frontiers in …, 2020 - frontiersin.org
… the blood compartment, drugs will be distributed to other organs … in Animal Models), the
newborn conventional piglet is … of animal models, including cats, dogs, guinea pigs, sheep, …
newborn conventional piglet is … of animal models, including cats, dogs, guinea pigs, sheep, …
Quantitative comparison of avian and mammalian physiologies for parameterization of physiologically based kinetic models
CG Scanes, J Witt, M Ebeling, S Schaller… - … in physiology, 2022 - frontiersin.org
… Moreover, linear regression was employed to analyze allometric relationships between
relative organ weight (organ weight as a percentage of body weight) and log 10 body …
relative organ weight (organ weight as a percentage of body weight) and log 10 body …