Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease
… important role for HCN channels and I f in long-term heart rate … state, it is associated with
sinus node dysfunction). This work … A screen of microRNAs in the mouse sinus node identified …
sinus node dysfunction). This work … A screen of microRNAs in the mouse sinus node identified …
[HTML][HTML] Beyond pacemaking: HCN channels in sinoatrial node function
… expressed in the SAN, and that expression … mouse model by inserting three point mutations
into the Hcn4 gene, thereby selectively switching off CDR of the channel (HCN4FEA mouse …
into the Hcn4 gene, thereby selectively switching off CDR of the channel (HCN4FEA mouse …
[HTML][HTML] HCN4 current during human sinoatrial node-like action potentials
M Hoekstra, ACG van Ginneken, R Wilders… - Progress in biophysics …, 2021 - Elsevier
… in mouse, which is in line with the much lower heart rate in human compared to … we expressed
HCN4 channels in cardiac myocyte progenitor cells (CMPCs). The use of such expression …
HCN4 channels in cardiac myocyte progenitor cells (CMPCs). The use of such expression …
[HTML][HTML] HCN channels in the heart
AS Depuydt, S Peigneur, J Tytgat - Current Cardiology Reviews, 2022 - ncbi.nlm.nih.gov
… This suggests that HCN4 channels influence basal excitability of mouse AV node cells, but
… They tested selectivity on HCN channels expressed in HEK cells. Subsequent tests showed …
… They tested selectivity on HCN channels expressed in HEK cells. Subsequent tests showed …
Cellular and molecular mechanisms of functional hierarchy of pacemaker clusters in the sinoatrial node: new insights into sick sinus syndrome
D Lang, AV Glukhov - Journal of Cardiovascular Development and …, 2021 - mdpi.com
… the expression of these regulators with their gene targets and found that sinus node cells …
However, as different isoforms of the HCN channels exhibit varied sensitivity to cAMP [80], …
However, as different isoforms of the HCN channels exhibit varied sensitivity to cAMP [80], …
Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
D Liang, J Xue, L Geng, L Zhou, B Lv, Q Zeng… - Nature …, 2021 - nature.com
… for cell adhesion and extracellular matrix organization, respectively. Cluster 4 highly … HCN
channels, K + channels, Ca 2+ channels, transporters and Ca 2+ regulators are all expressed …
channels, K + channels, Ca 2+ channels, transporters and Ca 2+ regulators are all expressed …
Depressed HCN4 function in the type 2 diabetic sinoatrial node
S Parveen, PHS Cheah, LPI Worthington… - Molecular and cellular …, 2023 - Springer
… Therefore, we aimed to investigate the function, expression and distribution of HCN4 channels
in the SAN of the type 2 diabetic heart. We hypothesised that type 2 diabetes in ZDF rats …
in the SAN of the type 2 diabetic heart. We hypothesised that type 2 diabetes in ZDF rats …
Pharmacologic approach to sinoatrial node dysfunction
P Mesirca, VV Fedorov, TJ Hund… - Annual review of …, 2021 - annualreviews.org
… TRPM7 is a divalent channel kinase abundantly expressed in mouse and human heart. …
We thank the organ procurement organization Lifeline of Ohio and the Division of Cardiac …
We thank the organ procurement organization Lifeline of Ohio and the Division of Cardiac …
Structural and electrical remodeling of the sinoatrial node in diabetes: new dimensions and perspectives
… HCN channel conducts the hyperpolarization current (funny … expressed in this article are
solely those of the authors and do not necessarily represent those of their affiliated organizations…
solely those of the authors and do not necessarily represent those of their affiliated organizations…
Molecular remodeling of cardiac sinus node associated with acute Chagas disease myocarditis
HO Rodríguez-Angulo, D Colombet-Naranjo, MC Maza… - Microorganisms, 2021 - mdpi.com
… the pattern of HCN4 channels’ expression in auricles and … To evaluate the activity of the HCN
channels, responsible for I… Δ heart rate of each mouse and calculated the linear regression. …
channels, responsible for I… Δ heart rate of each mouse and calculated the linear regression. …